STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY

The cutaneous, ophthalmic, and systemic reactions of normal rabbits to Gram-negative bacterial endotoxins have been compared with the classical reactions of bacterial hypersensitivity, and in each case certain similarities have been found. It has also been shown that the Shwartzman phenomenon can be...

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Detalles Bibliográficos
Autor principal: Stetson, Chandler A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1955
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136473/
https://www.ncbi.nlm.nih.gov/pubmed/14354110
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author Stetson, Chandler A.
author_facet Stetson, Chandler A.
author_sort Stetson, Chandler A.
collection PubMed
description The cutaneous, ophthalmic, and systemic reactions of normal rabbits to Gram-negative bacterial endotoxins have been compared with the classical reactions of bacterial hypersensitivity, and in each case certain similarities have been found. It has also been shown that the Shwartzman phenomenon can be reproduced with tuberculin, in BCG-vaccinated rabbits, and with suspensions or extracts of heat-killed Group A streptococci in rabbits previously sensitized to these bacteria. These considerations suggest the hypothesis that the biologic activity of endotoxins may be based on the existence in "normal" animals of delayed or tuberculin-type hypersensitivity to these materials.
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spelling pubmed-21364732008-04-17 STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY Stetson, Chandler A. J Exp Med Article The cutaneous, ophthalmic, and systemic reactions of normal rabbits to Gram-negative bacterial endotoxins have been compared with the classical reactions of bacterial hypersensitivity, and in each case certain similarities have been found. It has also been shown that the Shwartzman phenomenon can be reproduced with tuberculin, in BCG-vaccinated rabbits, and with suspensions or extracts of heat-killed Group A streptococci in rabbits previously sensitized to these bacteria. These considerations suggest the hypothesis that the biologic activity of endotoxins may be based on the existence in "normal" animals of delayed or tuberculin-type hypersensitivity to these materials. The Rockefeller University Press 1955-03-31 /pmc/articles/PMC2136473/ /pubmed/14354110 Text en Copyright © Copyright, 1955, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Stetson, Chandler A.
STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title_full STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title_fullStr STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title_full_unstemmed STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title_short STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : SIMILARITIES BETWEEN REACTIONS TO ENDOTOXINS AND CERTAIN REACTIONS OF BACTERIAL ALLERGY
title_sort studies on the mechanism of the shwartzman phenomenon : similarities between reactions to endotoxins and certain reactions of bacterial allergy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136473/
https://www.ncbi.nlm.nih.gov/pubmed/14354110
work_keys_str_mv AT stetsonchandlera studiesonthemechanismoftheshwartzmanphenomenonsimilaritiesbetweenreactionstoendotoxinsandcertainreactionsofbacterialallergy

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