A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS

The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity i...

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Detalles Bibliográficos
Autores principales: Martin, S. P., Cooper, C. D., Chaudhuri, S. N., Green, R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1955
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136487/
https://www.ncbi.nlm.nih.gov/pubmed/14367685
Descripción
Sumario:The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an ultraviolet absorption maxima at 250 mµ (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.

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