THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Skeggs, Leonard T., Kahn, Joseph R., Shumway, Norman P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1956
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136590/
https://www.ncbi.nlm.nih.gov/pubmed/13295487
_version_ 1782143154679447552
author Skeggs, Leonard T.
Kahn, Joseph R.
Shumway, Norman P.
author_facet Skeggs, Leonard T.
Kahn, Joseph R.
Shumway, Norman P.
author_sort Skeggs, Leonard T.
collection PubMed
description It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.
format Text
id pubmed-2136590
institution National Center for Biotechnology Information
language English
publishDate 1956
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21365902008-04-17 THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME Skeggs, Leonard T. Kahn, Joseph R. Shumway, Norman P. J Exp Med Article It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described. The Rockefeller University Press 1956-02-29 /pmc/articles/PMC2136590/ /pubmed/13295487 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Skeggs, Leonard T.
Kahn, Joseph R.
Shumway, Norman P.
THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title_full THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title_fullStr THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title_full_unstemmed THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title_short THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
title_sort preparation and function of the hypertensin-converting enzyme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136590/
https://www.ncbi.nlm.nih.gov/pubmed/13295487
work_keys_str_mv AT skeggsleonardt thepreparationandfunctionofthehypertensinconvertingenzyme
AT kahnjosephr thepreparationandfunctionofthehypertensinconvertingenzyme
AT shumwaynormanp thepreparationandfunctionofthehypertensinconvertingenzyme
AT skeggsleonardt preparationandfunctionofthehypertensinconvertingenzyme
AT kahnjosephr preparationandfunctionofthehypertensinconvertingenzyme
AT shumwaynormanp preparationandfunctionofthehypertensinconvertingenzyme

Ejemplares similares