IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE

The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid...

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Detalles Bibliográficos
Autores principales: Vazquez, Jacinto J., Dixon, Frank J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1956
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136616/
https://www.ncbi.nlm.nih.gov/pubmed/13367340
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author Vazquez, Jacinto J.
Dixon, Frank J.
author_facet Vazquez, Jacinto J.
Dixon, Frank J.
author_sort Vazquez, Jacinto J.
collection PubMed
description The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid deposits by the use of radioiodinated fluorescent antibody are reported. It is concluded that amyloid deposits in several organs from cases of secondary human amyloidosis and experimental amyloidosis in rabbits contain considerable concentrations of gamma globulin. The presence of gamma globulin in amyloid might be interpreted as either a metabolic deposition of circulating globulin present in high concentrations in the plasma or as a result of an immunologic reaction involving antigen and antibody.
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spelling pubmed-21366162008-04-17 IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE Vazquez, Jacinto J. Dixon, Frank J. J Exp Med Article The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid deposits by the use of radioiodinated fluorescent antibody are reported. It is concluded that amyloid deposits in several organs from cases of secondary human amyloidosis and experimental amyloidosis in rabbits contain considerable concentrations of gamma globulin. The presence of gamma globulin in amyloid might be interpreted as either a metabolic deposition of circulating globulin present in high concentrations in the plasma or as a result of an immunologic reaction involving antigen and antibody. The Rockefeller University Press 1956-10-31 /pmc/articles/PMC2136616/ /pubmed/13367340 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Vazquez, Jacinto J.
Dixon, Frank J.
IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title_full IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title_fullStr IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title_full_unstemmed IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title_short IMMUNOHISTOCHEMICAL ANALYSIS OF AMYLOID BY THE FLUORESCENCE TECHNIQUE
title_sort immunohistochemical analysis of amyloid by the fluorescence technique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136616/
https://www.ncbi.nlm.nih.gov/pubmed/13367340
work_keys_str_mv AT vazquezjacintoj immunohistochemicalanalysisofamyloidbythefluorescencetechnique
AT dixonfrankj immunohistochemicalanalysisofamyloidbythefluorescencetechnique

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