A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE

The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viru...

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Detalles Bibliográficos
Autores principales: Davenport, Fred M., Hennessy, Albert V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1956
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136633/
https://www.ncbi.nlm.nih.gov/pubmed/13332182
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author Davenport, Fred M.
Hennessy, Albert V.
author_facet Davenport, Fred M.
Hennessy, Albert V.
author_sort Davenport, Fred M.
collection PubMed
description The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses show that the antibody-forming mechanisms of children born after 1943 are oriented to strains of influenza A-prime; of recruits to strains of influenza A; and of persons over 30 years of age to a strain of swine influenza. It was shown that antibody response to heterotypic viruses appears to provide a serologic index of the amount of experience each of the segments of the general population studied have had with antigenic variants of influenza virus. Finally it was demonstrated that the antibody response of humans to strains of influenza A or influenza A-prime is remarkably uniform for isolates of each antigenic type.
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spelling pubmed-21366332008-04-17 A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE Davenport, Fred M. Hennessy, Albert V. J Exp Med Article The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses show that the antibody-forming mechanisms of children born after 1943 are oriented to strains of influenza A-prime; of recruits to strains of influenza A; and of persons over 30 years of age to a strain of swine influenza. It was shown that antibody response to heterotypic viruses appears to provide a serologic index of the amount of experience each of the segments of the general population studied have had with antigenic variants of influenza virus. Finally it was demonstrated that the antibody response of humans to strains of influenza A or influenza A-prime is remarkably uniform for isolates of each antigenic type. The Rockefeller University Press 1956-07-01 /pmc/articles/PMC2136633/ /pubmed/13332182 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Davenport, Fred M.
Hennessy, Albert V.
A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title_full A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title_fullStr A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title_full_unstemmed A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title_short A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
title_sort serologic recapitulation of past experiences with influenza a; antibody response to monovalent vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136633/
https://www.ncbi.nlm.nih.gov/pubmed/13332182
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