THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI

Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leu...

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Detalles Bibliográficos
Autor principal: Stetson, Chandler A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1956
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136644/
https://www.ncbi.nlm.nih.gov/pubmed/13376812
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author Stetson, Chandler A.
author_facet Stetson, Chandler A.
author_sort Stetson, Chandler A.
collection PubMed
description Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species.
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spelling pubmed-21366442008-04-17 THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI Stetson, Chandler A. J Exp Med Article Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species. The Rockefeller University Press 1956-11-30 /pmc/articles/PMC2136644/ /pubmed/13376812 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Stetson, Chandler A.
THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title_full THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title_fullStr THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title_full_unstemmed THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title_short THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI
title_sort endotoxic properties of lysates of group a hemolytic streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136644/
https://www.ncbi.nlm.nih.gov/pubmed/13376812
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