DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES

A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The method consists of intradermal injection of minute amounts of washed immune precipitates containing the antigen in question. Provided the specific precipitates are formed in...

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Detalles Bibliográficos
Autores principales: Uhr, Jonathan W., Salvin, S. B., Pappenheimer, A. M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136665/
https://www.ncbi.nlm.nih.gov/pubmed/13385403
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author Uhr, Jonathan W.
Salvin, S. B.
Pappenheimer, A. M.
author_facet Uhr, Jonathan W.
Salvin, S. B.
Pappenheimer, A. M.
author_sort Uhr, Jonathan W.
collection PubMed
description A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The method consists of intradermal injection of minute amounts of washed immune precipitates containing the antigen in question. Provided the specific precipitates are formed in the region of antibody excess, maximal sensitivity develops at least 2 to 3 weeks before detectable circulating antibody is formed in guinea pigs against the sensitizing antigen. Neither adjuvant nor killed acid-fast bacteria are required for induction of the delayed hypersensitive state although the degree of sensitization is considerably increased when the sensitizing material is incorporated in Freund's complete adjuvant. Characteristics of the "delayed" as opposed to the "immediate" hypersensitive states in the guinea pig are described and implications of the findings are discussed.
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spelling pubmed-21366652008-04-17 DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES Uhr, Jonathan W. Salvin, S. B. Pappenheimer, A. M. J Exp Med Article A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The method consists of intradermal injection of minute amounts of washed immune precipitates containing the antigen in question. Provided the specific precipitates are formed in the region of antibody excess, maximal sensitivity develops at least 2 to 3 weeks before detectable circulating antibody is formed in guinea pigs against the sensitizing antigen. Neither adjuvant nor killed acid-fast bacteria are required for induction of the delayed hypersensitive state although the degree of sensitization is considerably increased when the sensitizing material is incorporated in Freund's complete adjuvant. Characteristics of the "delayed" as opposed to the "immediate" hypersensitive states in the guinea pig are described and implications of the findings are discussed. The Rockefeller University Press 1957-01-01 /pmc/articles/PMC2136665/ /pubmed/13385403 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Uhr, Jonathan W.
Salvin, S. B.
Pappenheimer, A. M.
DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title_full DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title_fullStr DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title_full_unstemmed DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title_short DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES
title_sort delayed hypersensitivity : ii. induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136665/
https://www.ncbi.nlm.nih.gov/pubmed/13385403
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