SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS

The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy....

Descripción completa

Detalles Bibliográficos
Autor principal: Dziewiatkowski, Dominic D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136670/
https://www.ncbi.nlm.nih.gov/pubmed/13385407
_version_ 1782143173664964608
author Dziewiatkowski, Dominic D.
author_facet Dziewiatkowski, Dominic D.
author_sort Dziewiatkowski, Dominic D.
collection PubMed
description The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy. Daily supplements of 5 or 10 γ of L-thyroxine, started on the 28th day, increased the uptake of sulfur-35, although it did not reach normal in the 2 weeks of treatment. Autoradiograms of sections of tibiae and pelts confirmed the analytical data. The findings suggest that the synthesis of sulfomucopolysaccharides is depressed in thyroidectomized rats.
format Text
id pubmed-2136670
institution National Center for Biotechnology Information
language English
publishDate 1957
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21366702008-04-17 SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS Dziewiatkowski, Dominic D. J Exp Med Article The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy. Daily supplements of 5 or 10 γ of L-thyroxine, started on the 28th day, increased the uptake of sulfur-35, although it did not reach normal in the 2 weeks of treatment. Autoradiograms of sections of tibiae and pelts confirmed the analytical data. The findings suggest that the synthesis of sulfomucopolysaccharides is depressed in thyroidectomized rats. The Rockefeller University Press 1957-01-01 /pmc/articles/PMC2136670/ /pubmed/13385407 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dziewiatkowski, Dominic D.
SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title_full SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title_fullStr SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title_full_unstemmed SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title_short SYNTHESIS OF SULFOMUCOPOLYSACCHARIDES IN THYROIDECTOMIZED RATS
title_sort synthesis of sulfomucopolysaccharides in thyroidectomized rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136670/
https://www.ncbi.nlm.nih.gov/pubmed/13385407
work_keys_str_mv AT dziewiatkowskidominicd synthesisofsulfomucopolysaccharidesinthyroidectomizedrats

Ejemplares similares