ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO

Bacterial endotoxins in vitro are capable of shortening the coagulation time of normal whole blood, native platelet-rich and platelet-poor plasma, and the blood of a hemophilic patient in silicone but not in glass. The point in the coagulation system at which the endotoxins act has not been found bu...

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Detalles Bibliográficos
Autores principales: McKay, Donald G., Shapiro, Sandor S., Shanberge, Jacob N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136681/
https://www.ncbi.nlm.nih.gov/pubmed/13513906
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author McKay, Donald G.
Shapiro, Sandor S.
Shanberge, Jacob N.
author_facet McKay, Donald G.
Shapiro, Sandor S.
Shanberge, Jacob N.
author_sort McKay, Donald G.
collection PubMed
description Bacterial endotoxins in vitro are capable of shortening the coagulation time of normal whole blood, native platelet-rich and platelet-poor plasma, and the blood of a hemophilic patient in silicone but not in glass. The point in the coagulation system at which the endotoxins act has not been found but the search has been narrowed by the demonstration that these materials act independently of leukocytes and red blood cells, and do not act as preformed thromboplastin or thrombin. The shortening of the coagulation time in vivo 4 hours after endotoxin injection is probably through a different mechanism than in vitro.
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spelling pubmed-21366812008-04-17 ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO McKay, Donald G. Shapiro, Sandor S. Shanberge, Jacob N. J Exp Med Article Bacterial endotoxins in vitro are capable of shortening the coagulation time of normal whole blood, native platelet-rich and platelet-poor plasma, and the blood of a hemophilic patient in silicone but not in glass. The point in the coagulation system at which the endotoxins act has not been found but the search has been narrowed by the demonstration that these materials act independently of leukocytes and red blood cells, and do not act as preformed thromboplastin or thrombin. The shortening of the coagulation time in vivo 4 hours after endotoxin injection is probably through a different mechanism than in vitro. The Rockefeller University Press 1958-02-28 /pmc/articles/PMC2136681/ /pubmed/13513906 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McKay, Donald G.
Shapiro, Sandor S.
Shanberge, Jacob N.
ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title_full ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title_fullStr ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title_full_unstemmed ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title_short ALTERATIONS IN THE BLOOD COAGULATION SYSTEM INDUCED BY BACTERIAL ENDOTOXINS : II. IN VITRO
title_sort alterations in the blood coagulation system induced by bacterial endotoxins : ii. in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136681/
https://www.ncbi.nlm.nih.gov/pubmed/13513906
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