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STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN
Tolerance to the pyrogenic action of intravenously injected virus has been studied in rabbits given either PR8 strain of influenza A virus or Newcastle disease virus (NDV). The following findings suggest that the capacity of the animal to release an endogenous pyrogen is a critical factor. (a) Virus...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1958
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136682/ https://www.ncbi.nlm.nih.gov/pubmed/13513910 |
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author | Atkins, Elisha Huang, Wei Cheng |
author_facet | Atkins, Elisha Huang, Wei Cheng |
author_sort | Atkins, Elisha |
collection | PubMed |
description | Tolerance to the pyrogenic action of intravenously injected virus has been studied in rabbits given either PR8 strain of influenza A virus or Newcastle disease virus (NDV). The following findings suggest that the capacity of the animal to release an endogenous pyrogen is a critical factor. (a) Viruses produce fever by the release of endogenous pyrogen. (b) Tolerance to the pyrogenic effect of reinjected virus is associated with a decrease or absence of endogenous pyrogen production. (c) Tolerance to virus fever may be induced by the prior injection of endogenous pyrogen. (d) Cross-tolerance has been demonstrated between virus and bacterial endotoxin (typhoid vaccine), both of which cause the release of endogenous pyrogen. A difference has been noted in the mechanism of tolerance to successive injections of virus and of bacterial endotoxin. Repeated injections of endotoxins bring about an accelerated clearance of these substances from the blood stream with the result that there is a diminished stimulus to endogenous pyrogen production. Tolerance to virus, on the other hand, is unaccompanied by changes in the rate at which virus disappears from the circulation. It is postulated that circulating endogenous pyrogen, induced by the injection of a number of pyrogenic agents including viruses, temporarily suppresses the further release of endogenous pyrogen and thereby contributes to virus tolerance. |
format | Text |
id | pubmed-2136682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21366822008-04-17 STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN Atkins, Elisha Huang, Wei Cheng J Exp Med Article Tolerance to the pyrogenic action of intravenously injected virus has been studied in rabbits given either PR8 strain of influenza A virus or Newcastle disease virus (NDV). The following findings suggest that the capacity of the animal to release an endogenous pyrogen is a critical factor. (a) Viruses produce fever by the release of endogenous pyrogen. (b) Tolerance to the pyrogenic effect of reinjected virus is associated with a decrease or absence of endogenous pyrogen production. (c) Tolerance to virus fever may be induced by the prior injection of endogenous pyrogen. (d) Cross-tolerance has been demonstrated between virus and bacterial endotoxin (typhoid vaccine), both of which cause the release of endogenous pyrogen. A difference has been noted in the mechanism of tolerance to successive injections of virus and of bacterial endotoxin. Repeated injections of endotoxins bring about an accelerated clearance of these substances from the blood stream with the result that there is a diminished stimulus to endogenous pyrogen production. Tolerance to virus, on the other hand, is unaccompanied by changes in the rate at which virus disappears from the circulation. It is postulated that circulating endogenous pyrogen, induced by the injection of a number of pyrogenic agents including viruses, temporarily suppresses the further release of endogenous pyrogen and thereby contributes to virus tolerance. The Rockefeller University Press 1958-02-28 /pmc/articles/PMC2136682/ /pubmed/13513910 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Atkins, Elisha Huang, Wei Cheng STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title | STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title_full | STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title_fullStr | STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title_full_unstemmed | STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title_short | STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES : III. THE RELATION OF TOLERANCE TO THE PRODUCTION OF ENDOGENOUS PYROGEN |
title_sort | studies on the pathogenesis of fever with influenzal viruses : iii. the relation of tolerance to the production of endogenous pyrogen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136682/ https://www.ncbi.nlm.nih.gov/pubmed/13513910 |
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