STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS

Guinea pigs experimentally infected with mumps virus develop a delayed, hypersensitive skin reaction following the intradermal injection of heat-inactivated mumps virus. This in vivo hypersensitivity is accompanied by a state of cellular hypersensitivity which can be demonstrated in vitro by the add...

Descripción completa

Detalles Bibliográficos
Autores principales: Glasgow, Lowell A., Morgan, Herbert R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136728/
https://www.ncbi.nlm.nih.gov/pubmed/13439114
_version_ 1782143187240878080
author Glasgow, Lowell A.
Morgan, Herbert R.
author_facet Glasgow, Lowell A.
Morgan, Herbert R.
author_sort Glasgow, Lowell A.
collection PubMed
description Guinea pigs experimentally infected with mumps virus develop a delayed, hypersensitive skin reaction following the intradermal injection of heat-inactivated mumps virus. This in vivo hypersensitivity is accompanied by a state of cellular hypersensitivity which can be demonstrated in vitro by the addition of mumps viral antigen to cultures of splenic macrophages, following which they become less motile and undergo lysis. These observations support the hypothesis that the state of hypersensitivity which develops early in mumps virus infections may have a role in the pathogenesis of the disease.
format Text
id pubmed-2136728
institution National Center for Biotechnology Information
language English
publishDate 1957
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21367282008-04-17 STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS Glasgow, Lowell A. Morgan, Herbert R. J Exp Med Article Guinea pigs experimentally infected with mumps virus develop a delayed, hypersensitive skin reaction following the intradermal injection of heat-inactivated mumps virus. This in vivo hypersensitivity is accompanied by a state of cellular hypersensitivity which can be demonstrated in vitro by the addition of mumps viral antigen to cultures of splenic macrophages, following which they become less motile and undergo lysis. These observations support the hypothesis that the state of hypersensitivity which develops early in mumps virus infections may have a role in the pathogenesis of the disease. The Rockefeller University Press 1957-07-01 /pmc/articles/PMC2136728/ /pubmed/13439114 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Glasgow, Lowell A.
Morgan, Herbert R.
STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title_full STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title_fullStr STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title_full_unstemmed STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title_short STUDIES OF DELAYED HYPERSENSITIVITY IN VITRO : II. DELAYED HYPERSENSITIVITY IN EXPERIMENTAL MUMPS VIRUS INFECTIONS
title_sort studies of delayed hypersensitivity in vitro : ii. delayed hypersensitivity in experimental mumps virus infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136728/
https://www.ncbi.nlm.nih.gov/pubmed/13439114
work_keys_str_mv AT glasgowlowella studiesofdelayedhypersensitivityinvitroiidelayedhypersensitivityinexperimentalmumpsvirusinfections
AT morganherbertr studiesofdelayedhypersensitivityinvitroiidelayedhypersensitivityinexperimentalmumpsvirusinfections

Ejemplares similares