THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS

Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics...

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Autores principales: Rutenburg, Alexander M., Sonnenblick, Edmund, Koven, Irving, Aprahamian, H. Arto, Reiner, Leopold, Fine, Jacob
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136738/
https://www.ncbi.nlm.nih.gov/pubmed/13439110
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author Rutenburg, Alexander M.
Sonnenblick, Edmund
Koven, Irving
Aprahamian, H. Arto
Reiner, Leopold
Fine, Jacob
author_facet Rutenburg, Alexander M.
Sonnenblick, Edmund
Koven, Irving
Aprahamian, H. Arto
Reiner, Leopold
Fine, Jacob
author_sort Rutenburg, Alexander M.
collection PubMed
description Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics added to the daily diet prevent the development of cirrhosis in most rats for as long as 750 days. The superiority of non-absorbable antibiotics to absorbable antibiotics excludes a systemic effect of the antibiotics and demonstrates that intestinal bacteria are largely, if not wholly, responsible for the cirrhosis in rats on a choline-deficient diet.
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spelling pubmed-21367382008-04-17 THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS Rutenburg, Alexander M. Sonnenblick, Edmund Koven, Irving Aprahamian, H. Arto Reiner, Leopold Fine, Jacob J Exp Med Article Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics added to the daily diet prevent the development of cirrhosis in most rats for as long as 750 days. The superiority of non-absorbable antibiotics to absorbable antibiotics excludes a systemic effect of the antibiotics and demonstrates that intestinal bacteria are largely, if not wholly, responsible for the cirrhosis in rats on a choline-deficient diet. The Rockefeller University Press 1957-07-01 /pmc/articles/PMC2136738/ /pubmed/13439110 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rutenburg, Alexander M.
Sonnenblick, Edmund
Koven, Irving
Aprahamian, H. Arto
Reiner, Leopold
Fine, Jacob
THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title_full THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title_fullStr THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title_full_unstemmed THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title_short THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
title_sort role of intestinal bacteria in the development of dietary cirrhosis in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136738/
https://www.ncbi.nlm.nih.gov/pubmed/13439110
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