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DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS
The desexycorticosterone-mimetic action of ammoniated glycyrrhizin on electrolyte and water metabolism and on pituitary-adrenal function, was demonstrated in rats. Retention of sodium and water was observed in both intact and adrenalectomized rats during 4 hour minerosteroid assays, the degree of re...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1957
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136773/ https://www.ncbi.nlm.nih.gov/pubmed/13463251 |
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author | Kraus, Shirley D. |
author_facet | Kraus, Shirley D. |
author_sort | Kraus, Shirley D. |
collection | PubMed |
description | The desexycorticosterone-mimetic action of ammoniated glycyrrhizin on electrolyte and water metabolism and on pituitary-adrenal function, was demonstrated in rats. Retention of sodium and water was observed in both intact and adrenalectomized rats during 4 hour minerosteroid assays, the degree of retention being a function of log dose. In intact rats, the antidiuretic effect of glycyrrhizin was immediate and cumulative, while retention of sodium appeared only after a latent period and did not increase with time. Adrenalectomized rats, 3 days after the operation, showed a more marked antidiuretic effect than intact rats, but no greater retention of sodium. Rats receiving glycyrrhizin prior to histamine stress showed a marked decrease in adrenal ascorbic acid depletion, suggesting that glycyrrhizin had suppressed the output of ACTH. Whether glycyrrhizin acts on the same target organ as desoxycorticosterone in producing sodium and water retention is still an open question. However, the fact that it is capable of producing a pituitary-adrenal inhibition which resembles that of naturally occurring adrenal steroids is further evidence of the strong pharmacological resemblance between glycyrrhizin and desoxycorticosterone. |
format | Text |
id | pubmed-2136773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1957 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21367732008-04-17 DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS Kraus, Shirley D. J Exp Med Article The desexycorticosterone-mimetic action of ammoniated glycyrrhizin on electrolyte and water metabolism and on pituitary-adrenal function, was demonstrated in rats. Retention of sodium and water was observed in both intact and adrenalectomized rats during 4 hour minerosteroid assays, the degree of retention being a function of log dose. In intact rats, the antidiuretic effect of glycyrrhizin was immediate and cumulative, while retention of sodium appeared only after a latent period and did not increase with time. Adrenalectomized rats, 3 days after the operation, showed a more marked antidiuretic effect than intact rats, but no greater retention of sodium. Rats receiving glycyrrhizin prior to histamine stress showed a marked decrease in adrenal ascorbic acid depletion, suggesting that glycyrrhizin had suppressed the output of ACTH. Whether glycyrrhizin acts on the same target organ as desoxycorticosterone in producing sodium and water retention is still an open question. However, the fact that it is capable of producing a pituitary-adrenal inhibition which resembles that of naturally occurring adrenal steroids is further evidence of the strong pharmacological resemblance between glycyrrhizin and desoxycorticosterone. The Rockefeller University Press 1957-09-01 /pmc/articles/PMC2136773/ /pubmed/13463251 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Kraus, Shirley D. DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title | DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title_full | DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title_fullStr | DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title_full_unstemmed | DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title_short | DESOXYCORTICOSTERONE-MIMETIC ACTION OF AMMONIATED GLYCYRRHIZIN IN RATS |
title_sort | desoxycorticosterone-mimetic action of ammoniated glycyrrhizin in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136773/ https://www.ncbi.nlm.nih.gov/pubmed/13463251 |
work_keys_str_mv | AT krausshirleyd desoxycorticosteronemimeticactionofammoniatedglycyrrhizininrats |