STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS

An endogenous pyrogen, which is indistinguishable from leucocytic pyrogen, has been demonstrated in the blood streams of rabbits with fevers caused by experimental pneumococcal and streptococcal infections. Like the endogenous pyrogen previously detected in the serum of animals with fever produced b...

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Detalles Bibliográficos
Autores principales: King, M. Kenton, Wood, W. Barry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136793/
https://www.ncbi.nlm.nih.gov/pubmed/13491764
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author King, M. Kenton
Wood, W. Barry
author_facet King, M. Kenton
Wood, W. Barry
author_sort King, M. Kenton
collection PubMed
description An endogenous pyrogen, which is indistinguishable from leucocytic pyrogen, has been demonstrated in the blood streams of rabbits with fevers caused by experimental pneumococcal and streptococcal infections. Like the endogenous pyrogen previously detected in the serum of animals with fever produced by the intravenous injection of typhoid vaccine, the newly discovered circulating factor acts directly upon the thermoregulatory centers of the brain. Its origin from polymorphonuclear leucocytes at the site of infection appears to have been established. The possible relationship of this circulating endogenous pyrogen to the pathogenesis of other forms of fever is discussed.
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spelling pubmed-21367932008-04-17 STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS King, M. Kenton Wood, W. Barry J Exp Med Article An endogenous pyrogen, which is indistinguishable from leucocytic pyrogen, has been demonstrated in the blood streams of rabbits with fevers caused by experimental pneumococcal and streptococcal infections. Like the endogenous pyrogen previously detected in the serum of animals with fever produced by the intravenous injection of typhoid vaccine, the newly discovered circulating factor acts directly upon the thermoregulatory centers of the brain. Its origin from polymorphonuclear leucocytes at the site of infection appears to have been established. The possible relationship of this circulating endogenous pyrogen to the pathogenesis of other forms of fever is discussed. The Rockefeller University Press 1958-01-31 /pmc/articles/PMC2136793/ /pubmed/13491764 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
King, M. Kenton
Wood, W. Barry
STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title_full STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title_fullStr STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title_full_unstemmed STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title_short STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS
title_sort studies on the pathogenesis of fever : v. the relation of circulating endogenous pyrogen to the fever of acute bacterial infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136793/
https://www.ncbi.nlm.nih.gov/pubmed/13491764
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