MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS

Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal γ(1)-globulin and the hete...

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Detalles Bibliográficos
Autores principales: Korngold, Leonhard, Van Leeuwen, Gerda
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136806/
https://www.ncbi.nlm.nih.gov/pubmed/13475607
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author Korngold, Leonhard
Van Leeuwen, Gerda
author_facet Korngold, Leonhard
Van Leeuwen, Gerda
author_sort Korngold, Leonhard
collection PubMed
description Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal γ(1)-globulin and the heterologous pathological 19S macroglobulins. Exhaustive absorption of these antisera with normal γ-globulins rendered them specific for the homologous macroglobulins. The antigenic properties of the pathological macroglobulins indicate that these proteins are abnormal.
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spelling pubmed-21368062008-04-17 MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS Korngold, Leonhard Van Leeuwen, Gerda J Exp Med Article Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal γ(1)-globulin and the heterologous pathological 19S macroglobulins. Exhaustive absorption of these antisera with normal γ-globulins rendered them specific for the homologous macroglobulins. The antigenic properties of the pathological macroglobulins indicate that these proteins are abnormal. The Rockefeller University Press 1957-09-30 /pmc/articles/PMC2136806/ /pubmed/13475607 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Korngold, Leonhard
Van Leeuwen, Gerda
MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title_full MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title_fullStr MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title_full_unstemmed MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title_short MACROGLOBULINEMIA : II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS
title_sort macroglobulinemia : ii. antisera specific for pathological macroglobulins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136806/
https://www.ncbi.nlm.nih.gov/pubmed/13475607
work_keys_str_mv AT korngoldleonhard macroglobulinemiaiiantiseraspecificforpathologicalmacroglobulins
AT vanleeuwengerda macroglobulinemiaiiantiseraspecificforpathologicalmacroglobulins

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