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POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR

Antigens present in poliovirus concentrates react with antibodies present in the serum of hyperimmunized monkeys to give type-specific precipitates. One or more bands of precipitate can be formed wherever such homotypic reactants, diffusing into an agar gel, meet in sufficient concentration and in e...

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Detalles Bibliográficos
Autor principal: Le Bouvier, George L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1957
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136827/
https://www.ncbi.nlm.nih.gov/pubmed/13475622
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author Le Bouvier, George L.
author_facet Le Bouvier, George L.
author_sort Le Bouvier, George L.
collection PubMed
description Antigens present in poliovirus concentrates react with antibodies present in the serum of hyperimmunized monkeys to give type-specific precipitates. One or more bands of precipitate can be formed wherever such homotypic reactants, diffusing into an agar gel, meet in sufficient concentration and in equivalent proportions. No qualitative differences have been detected between the type-specific reactions given by different strains of the same virus type; and no precipitates have been seen which could be called "group-specific." Non-specific precipitates have occasionally been observed. Type-specific poliovirus precipitins are found in the serum of poliomyelitis patients. Their concentration has been measured by a standardized method. They tend to develop in parallel with neutralizing antibodies against the same virus type, increasing in amount during the first weeks of illness in those patients who show concurrent neutralizing antibody rises. The precipitation reaction has proved valuable in the antigenic analysis of polioviruses. Its general adoption as a diagnostic procedure is perhaps unlikely; but it may be well worth applying for special purposes.
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spelling pubmed-21368272008-04-17 POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR Le Bouvier, George L. J Exp Med Article Antigens present in poliovirus concentrates react with antibodies present in the serum of hyperimmunized monkeys to give type-specific precipitates. One or more bands of precipitate can be formed wherever such homotypic reactants, diffusing into an agar gel, meet in sufficient concentration and in equivalent proportions. No qualitative differences have been detected between the type-specific reactions given by different strains of the same virus type; and no precipitates have been seen which could be called "group-specific." Non-specific precipitates have occasionally been observed. Type-specific poliovirus precipitins are found in the serum of poliomyelitis patients. Their concentration has been measured by a standardized method. They tend to develop in parallel with neutralizing antibodies against the same virus type, increasing in amount during the first weeks of illness in those patients who show concurrent neutralizing antibody rises. The precipitation reaction has proved valuable in the antigenic analysis of polioviruses. Its general adoption as a diagnostic procedure is perhaps unlikely; but it may be well worth applying for special purposes. The Rockefeller University Press 1957-10-31 /pmc/articles/PMC2136827/ /pubmed/13475622 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Le Bouvier, George L.
POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title_full POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title_fullStr POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title_full_unstemmed POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title_short POLIOVIRUS PRECIPITINS : A STUDY BY MEANS OF DIFFUSION IN AGAR
title_sort poliovirus precipitins : a study by means of diffusion in agar
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136827/
https://www.ncbi.nlm.nih.gov/pubmed/13475622
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