EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D

One day old chicks were fed a vitamin D-deficient diet for 3 weeks. Some were then given an oral dose of vitamin D and sacrificed at various times thereafter. The tibiae were x-rayed; demineralized sections were stained for neutral polysaccharides and sulfated mucopolysaccharides; other specimens we...

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Detalles Bibliográficos
Autores principales: Bélanger, Leonard F., Migicovsky, B. B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136856/
https://www.ncbi.nlm.nih.gov/pubmed/13539307
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author Bélanger, Leonard F.
Migicovsky, B. B.
author_facet Bélanger, Leonard F.
Migicovsky, B. B.
author_sort Bélanger, Leonard F.
collection PubMed
description One day old chicks were fed a vitamin D-deficient diet for 3 weeks. Some were then given an oral dose of vitamin D and sacrificed at various times thereafter. The tibiae were x-rayed; demineralized sections were stained for neutral polysaccharides and sulfated mucopolysaccharides; other specimens were ashed; and others still were autoradiographed to determine their uptake of Ca(45) in vitro. Mineralization reappeared in the treated animals after 2 days, along with new P.A.S.-positive spicules. Earlier, the immature cartilage rapidly matured morphologically. At the same time, the rachitic matrix, highly concentrated in cation binder, presumably chondroitin sulfate, lost this material progressively.
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spelling pubmed-21368562008-04-17 EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D Bélanger, Leonard F. Migicovsky, B. B. J Exp Med Article One day old chicks were fed a vitamin D-deficient diet for 3 weeks. Some were then given an oral dose of vitamin D and sacrificed at various times thereafter. The tibiae were x-rayed; demineralized sections were stained for neutral polysaccharides and sulfated mucopolysaccharides; other specimens were ashed; and others still were autoradiographed to determine their uptake of Ca(45) in vitro. Mineralization reappeared in the treated animals after 2 days, along with new P.A.S.-positive spicules. Earlier, the immature cartilage rapidly matured morphologically. At the same time, the rachitic matrix, highly concentrated in cation binder, presumably chondroitin sulfate, lost this material progressively. The Rockefeller University Press 1958-06-01 /pmc/articles/PMC2136856/ /pubmed/13539307 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bélanger, Leonard F.
Migicovsky, B. B.
EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title_full EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title_fullStr EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title_full_unstemmed EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title_short EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
title_sort early changes at the epiphysis of rachitic chicks, following administration of vitamin d
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136856/
https://www.ncbi.nlm.nih.gov/pubmed/13539307
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AT migicovskybb earlychangesattheepiphysisofrachiticchicksfollowingadministrationofvitamind

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