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IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS

The phenomenon of immunological unresponsiveness induced in the neonatal rabbit by a single injection of a defined protein antigen, has been characterized semiquantitatively, and studies bearing upon the mechanism of such unresponsiveness have been presented. A single intraperitoneal injection at bi...

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Autores principales: Smith, Richard T., Bridges, Robert A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136862/
https://www.ncbi.nlm.nih.gov/pubmed/13563758
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author Smith, Richard T.
Bridges, Robert A.
author_facet Smith, Richard T.
Bridges, Robert A.
author_sort Smith, Richard T.
collection PubMed
description The phenomenon of immunological unresponsiveness induced in the neonatal rabbit by a single injection of a defined protein antigen, has been characterized semiquantitatively, and studies bearing upon the mechanism of such unresponsiveness have been presented. A single intraperitoneal injection at birth of 10 to 100 mg. BSA, HGG, ovalbumin, or a human macroglobulin, or an oral feeding of 100 mg. BSA, induced a state of unresponsiveness lasting at least 90 to 120 days. 100 mg. BSA given from birth to 17 days of age, but not later, produced unresponsiveness of 90 to 120 days' duration. Data are presented which show that the duration of unresponsiveness is finite and related to the amount of antigen given at birth, and that it may be indefinitely prolonged by repeated injections of antigen. Disappearance of injected antigen in the unresponsive animal was exponential with time, with no accelerated or immune phase. Administration of the antigen in adjuvants resulted in significant shortening of the duration of unresponsiveness. The transfer of immune cells to the unresponsive host while resulting in vicarious antibody formation, did not affect the underlying unresponsive state. Negative results of attempts to produce unresponsiveness to a variety of bacterial antigens are presented. The implications of the data are discussed, particularly in reference to the other experimental models of immunological tolerance, and to the various theories of acquired immunity. It is clear that any satisfactory theoretical explanation of acquired immunity will have to account simultaneously for the phenomena of immune tolerance.
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spelling pubmed-21368622008-04-17 IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS Smith, Richard T. Bridges, Robert A. J Exp Med Article The phenomenon of immunological unresponsiveness induced in the neonatal rabbit by a single injection of a defined protein antigen, has been characterized semiquantitatively, and studies bearing upon the mechanism of such unresponsiveness have been presented. A single intraperitoneal injection at birth of 10 to 100 mg. BSA, HGG, ovalbumin, or a human macroglobulin, or an oral feeding of 100 mg. BSA, induced a state of unresponsiveness lasting at least 90 to 120 days. 100 mg. BSA given from birth to 17 days of age, but not later, produced unresponsiveness of 90 to 120 days' duration. Data are presented which show that the duration of unresponsiveness is finite and related to the amount of antigen given at birth, and that it may be indefinitely prolonged by repeated injections of antigen. Disappearance of injected antigen in the unresponsive animal was exponential with time, with no accelerated or immune phase. Administration of the antigen in adjuvants resulted in significant shortening of the duration of unresponsiveness. The transfer of immune cells to the unresponsive host while resulting in vicarious antibody formation, did not affect the underlying unresponsive state. Negative results of attempts to produce unresponsiveness to a variety of bacterial antigens are presented. The implications of the data are discussed, particularly in reference to the other experimental models of immunological tolerance, and to the various theories of acquired immunity. It is clear that any satisfactory theoretical explanation of acquired immunity will have to account simultaneously for the phenomena of immune tolerance. The Rockefeller University Press 1958-08-01 /pmc/articles/PMC2136862/ /pubmed/13563758 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Smith, Richard T.
Bridges, Robert A.
IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title_full IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title_fullStr IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title_full_unstemmed IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title_short IMMUNOLOGICAL UNRESPONSIVENESS IN RABBITS PRODUCED BY NEONATAL INJECTION OF DEFINED ANTIGENS
title_sort immunological unresponsiveness in rabbits produced by neonatal injection of defined antigens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136862/
https://www.ncbi.nlm.nih.gov/pubmed/13563758
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