GAMMA GLOBULINS IN GERM-FREE RATS

The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins su...

Descripción completa

Detalles Bibliográficos
Autores principales: Gustafsson, Bengt E., Laurell, Carl-Bertil
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1958
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136869/
https://www.ncbi.nlm.nih.gov/pubmed/13563759
_version_ 1782143220412579840
author Gustafsson, Bengt E.
Laurell, Carl-Bertil
author_facet Gustafsson, Bengt E.
Laurell, Carl-Bertil
author_sort Gustafsson, Bengt E.
collection PubMed
description The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins survive equally long in the circulation in germ-free animals as in controls, the production of gamma globulins in normal rats is three times as rapid as in germ-free rats. This suggests that the normal flora of microorganisms is an important stimulant for the gamma globulin-producing cells.
format Text
id pubmed-2136869
institution National Center for Biotechnology Information
language English
publishDate 1958
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21368692008-04-17 GAMMA GLOBULINS IN GERM-FREE RATS Gustafsson, Bengt E. Laurell, Carl-Bertil J Exp Med Article The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins survive equally long in the circulation in germ-free animals as in controls, the production of gamma globulins in normal rats is three times as rapid as in germ-free rats. This suggests that the normal flora of microorganisms is an important stimulant for the gamma globulin-producing cells. The Rockefeller University Press 1958-08-01 /pmc/articles/PMC2136869/ /pubmed/13563759 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gustafsson, Bengt E.
Laurell, Carl-Bertil
GAMMA GLOBULINS IN GERM-FREE RATS
title GAMMA GLOBULINS IN GERM-FREE RATS
title_full GAMMA GLOBULINS IN GERM-FREE RATS
title_fullStr GAMMA GLOBULINS IN GERM-FREE RATS
title_full_unstemmed GAMMA GLOBULINS IN GERM-FREE RATS
title_short GAMMA GLOBULINS IN GERM-FREE RATS
title_sort gamma globulins in germ-free rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136869/
https://www.ncbi.nlm.nih.gov/pubmed/13563759
work_keys_str_mv AT gustafssonbengte gammaglobulinsingermfreerats
AT laurellcarlbertil gammaglobulinsingermfreerats

Ejemplares similares