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OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI
Approximately 50 per cent of Group A, Type 3 streptococci contain a hitherto undescribed antigen found only in Group A, Type 3 organisms. It is serologically distinct from Type 3 M antigen and is designated as 3 R antigen. Strains containing 3 R antigen but no Type 3 M antigen are "glossy,"...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1958
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136879/ https://www.ncbi.nlm.nih.gov/pubmed/13575670 |
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author | Lancefield, Rebecca C. |
author_facet | Lancefield, Rebecca C. |
author_sort | Lancefield, Rebecca C. |
collection | PubMed |
description | Approximately 50 per cent of Group A, Type 3 streptococci contain a hitherto undescribed antigen found only in Group A, Type 3 organisms. It is serologically distinct from Type 3 M antigen and is designated as 3 R antigen. Strains containing 3 R antigen but no Type 3 M antigen are "glossy," avirulent Type 3 variants. These strains can be obtained by repeated transfers of virulent M-containing streptococci in artificial media under unfavorable conditions of growth. These degraded streptococci recover Type 3 M antigen during serial passage through mice. The amount of 3 R antigen in a strain is not affected by a decrease or increase in M antigen. The 3 R antigen is unrelated to virulence. Antibodies to this antigen do not protect mice against infection or promote phagocytosis in bactericidal tests. The 3 R antigen-antibody system can give rise to confusion in M-precipitin reactions. In all these properties 3 R antigen is similar to 28 R antigen, although in certain other properties the two R antigens are not identical. They are serologically distinct. Virulence and ability to grow in normal human blood under the conditions of the bactericidal test are correlated with the presence of M antigen of Group A, Type 3 streptococci. Mouse protection and specific inhibition of growth of Type 3 streptococci by phagocytosis in bactericidal tests are associated with the presence of Type 3 anti-M antibodies. |
format | Text |
id | pubmed-2136879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21368792008-04-17 OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI Lancefield, Rebecca C. J Exp Med Article Approximately 50 per cent of Group A, Type 3 streptococci contain a hitherto undescribed antigen found only in Group A, Type 3 organisms. It is serologically distinct from Type 3 M antigen and is designated as 3 R antigen. Strains containing 3 R antigen but no Type 3 M antigen are "glossy," avirulent Type 3 variants. These strains can be obtained by repeated transfers of virulent M-containing streptococci in artificial media under unfavorable conditions of growth. These degraded streptococci recover Type 3 M antigen during serial passage through mice. The amount of 3 R antigen in a strain is not affected by a decrease or increase in M antigen. The 3 R antigen is unrelated to virulence. Antibodies to this antigen do not protect mice against infection or promote phagocytosis in bactericidal tests. The 3 R antigen-antibody system can give rise to confusion in M-precipitin reactions. In all these properties 3 R antigen is similar to 28 R antigen, although in certain other properties the two R antigens are not identical. They are serologically distinct. Virulence and ability to grow in normal human blood under the conditions of the bactericidal test are correlated with the presence of M antigen of Group A, Type 3 streptococci. Mouse protection and specific inhibition of growth of Type 3 streptococci by phagocytosis in bactericidal tests are associated with the presence of Type 3 anti-M antibodies. The Rockefeller University Press 1958-09-01 /pmc/articles/PMC2136879/ /pubmed/13575670 Text en Copyright © Copyright, 1958, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Lancefield, Rebecca C. OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title | OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title_full | OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title_fullStr | OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title_full_unstemmed | OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title_short | OCCURRENCE OF R ANTIGEN SPECIFIC FOR GROUP A TYPE 3 STREPTOCOCCI |
title_sort | occurrence of r antigen specific for group a type 3 streptococci |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136879/ https://www.ncbi.nlm.nih.gov/pubmed/13575670 |
work_keys_str_mv | AT lancefieldrebeccac occurrenceofrantigenspecificforgroupatype3streptococci AT occurrenceofrantigenspecificforgroupatype3streptococci |