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ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES
In normal rabbits subcutaneous granulomata produced by the injection of a spore suspension of Rhizopus oryzae remained confined to the site of inoculation, showed no fungus proliferation, no longer yielded the agent on culture 10 weeks after inoculation, and eventually healed. Similar well establish...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1958
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136893/ https://www.ncbi.nlm.nih.gov/pubmed/13549649 |
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author | Sheldon, Walter H. Bauer, Heinz |
author_facet | Sheldon, Walter H. Bauer, Heinz |
author_sort | Sheldon, Walter H. |
collection | PubMed |
description | In normal rabbits subcutaneous granulomata produced by the injection of a spore suspension of Rhizopus oryzae remained confined to the site of inoculation, showed no fungus proliferation, no longer yielded the agent on culture 10 weeks after inoculation, and eventually healed. Similar well established granulomata in rabbits with acute alloxan diabetes induced 8, 10, and 15 days after injection of the fungus uniformly showed activation of the infection. This occurred only in animals showing acetonuria. In these animals the skin lesions showed proliferation of the fungus frequently associated with invasion and early necrosis of the granuloma wall. In some instances, spread of the infection to adjacent tissues with invasion of blood vessels had occurred. These experiments illustrate that changes in host metabolism can activate a preexisting quiescent infection. |
format | Text |
id | pubmed-2136893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21368932008-04-17 ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES Sheldon, Walter H. Bauer, Heinz J Exp Med Article In normal rabbits subcutaneous granulomata produced by the injection of a spore suspension of Rhizopus oryzae remained confined to the site of inoculation, showed no fungus proliferation, no longer yielded the agent on culture 10 weeks after inoculation, and eventually healed. Similar well established granulomata in rabbits with acute alloxan diabetes induced 8, 10, and 15 days after injection of the fungus uniformly showed activation of the infection. This occurred only in animals showing acetonuria. In these animals the skin lesions showed proliferation of the fungus frequently associated with invasion and early necrosis of the granuloma wall. In some instances, spread of the infection to adjacent tissues with invasion of blood vessels had occurred. These experiments illustrate that changes in host metabolism can activate a preexisting quiescent infection. The Rockefeller University Press 1958-07-01 /pmc/articles/PMC2136893/ /pubmed/13549649 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Sheldon, Walter H. Bauer, Heinz ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title | ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title_full | ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title_fullStr | ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title_full_unstemmed | ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title_short | ACTIVATION OF QUIESCENT MUCORMYCOTIC GRANULOMATA IN RABBITS BY INDUCTION OF ACUTE ALLOXAN DIABETES |
title_sort | activation of quiescent mucormycotic granulomata in rabbits by induction of acute alloxan diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136893/ https://www.ncbi.nlm.nih.gov/pubmed/13549649 |
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