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DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS
Guinea pigs rendered hypersensitive (delayed-type) to protein antigen can be completely and specifically desensitized by a single injection containing a sufficient amount of the corresponding antigen. Although 1 to 2 mg. of specific antigen are required for complete desensitization, as little as 20...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1958
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136924/ https://www.ncbi.nlm.nih.gov/pubmed/13598818 |
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author | Uhr, Jonathan W. Pappenheimer, A. M. |
author_facet | Uhr, Jonathan W. Pappenheimer, A. M. |
author_sort | Uhr, Jonathan W. |
collection | PubMed |
description | Guinea pigs rendered hypersensitive (delayed-type) to protein antigen can be completely and specifically desensitized by a single injection containing a sufficient amount of the corresponding antigen. Although 1 to 2 mg. of specific antigen are required for complete desensitization, as little as 20 µg. suffices to decrease the size of specific skin reactions in sensitized animals. The duration of non-reactivity lengthens as the amount of antigen in the desensitizing injection is increased, but skin reactivity eventually returns and is accompanied by the appearance of excess circulating antibody. Desensitization can be accomplished with the antigen-antibody complex as well as by "free" antigen. The appearance of delayed skin reactions can be prevented in fully sensitized animals by intravenous desensitization 2 or more hours after intradermal challenge or by simply skin testing with a desensitizing dose of specific antigen. Injection of a desensitizing dose of antigen into specifically sensitized animals also results in a transient anergic state, the implications of which are discussed. |
format | Text |
id | pubmed-2136924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21369242008-04-17 DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS Uhr, Jonathan W. Pappenheimer, A. M. J Exp Med Article Guinea pigs rendered hypersensitive (delayed-type) to protein antigen can be completely and specifically desensitized by a single injection containing a sufficient amount of the corresponding antigen. Although 1 to 2 mg. of specific antigen are required for complete desensitization, as little as 20 µg. suffices to decrease the size of specific skin reactions in sensitized animals. The duration of non-reactivity lengthens as the amount of antigen in the desensitizing injection is increased, but skin reactivity eventually returns and is accompanied by the appearance of excess circulating antibody. Desensitization can be accomplished with the antigen-antibody complex as well as by "free" antigen. The appearance of delayed skin reactions can be prevented in fully sensitized animals by intravenous desensitization 2 or more hours after intradermal challenge or by simply skin testing with a desensitizing dose of specific antigen. Injection of a desensitizing dose of antigen into specifically sensitized animals also results in a transient anergic state, the implications of which are discussed. The Rockefeller University Press 1958-11-30 /pmc/articles/PMC2136924/ /pubmed/13598818 Text en Copyright © Copyright, 1958, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Uhr, Jonathan W. Pappenheimer, A. M. DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title | DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title_full | DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title_fullStr | DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title_full_unstemmed | DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title_short | DELAYED HYPERSENSITIVITY : III. SPECIFIC DESENSITIZATION OF GUINEA PIGS SENSITIZED TO PROTEIN ANTIGENS |
title_sort | delayed hypersensitivity : iii. specific desensitization of guinea pigs sensitized to protein antigens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136924/ https://www.ncbi.nlm.nih.gov/pubmed/13598818 |
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