AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION

Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immuniz...

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Detalles Bibliográficos
Autores principales: Robbins, John, Stetson, Chandler A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136934/
https://www.ncbi.nlm.nih.gov/pubmed/13611160
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author Robbins, John
Stetson, Chandler A.
author_facet Robbins, John
Stetson, Chandler A.
author_sort Robbins, John
collection PubMed
description Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the effect. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. This effect of antigen-antibody interaction may be involved in the production of tissue damage in vivo.
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spelling pubmed-21369342008-04-17 AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION Robbins, John Stetson, Chandler A. J Exp Med Article Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the effect. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. This effect of antigen-antibody interaction may be involved in the production of tissue damage in vivo. The Rockefeller University Press 1959-01-01 /pmc/articles/PMC2136934/ /pubmed/13611160 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Robbins, John
Stetson, Chandler A.
AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title_full AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title_fullStr AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title_full_unstemmed AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title_short AN EFFECT OF ANTIGEN-ANTIBODY INTERACTION ON BLOOD COAGULATION
title_sort effect of antigen-antibody interaction on blood coagulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136934/
https://www.ncbi.nlm.nih.gov/pubmed/13611160
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