THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY

Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obv...

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Detalles Bibliográficos
Autores principales: Ishizaka, Kimishige, Ishizaka, Teruko, Campbell, Dan H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136941/
https://www.ncbi.nlm.nih.gov/pubmed/13620844
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author Ishizaka, Kimishige
Ishizaka, Teruko
Campbell, Dan H.
author_facet Ishizaka, Kimishige
Ishizaka, Teruko
Campbell, Dan H.
author_sort Ishizaka, Kimishige
collection PubMed
description Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.
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spelling pubmed-21369412008-04-17 THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY Ishizaka, Kimishige Ishizaka, Teruko Campbell, Dan H. J Exp Med Article Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented. The Rockefeller University Press 1959-01-31 /pmc/articles/PMC2136941/ /pubmed/13620844 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ishizaka, Kimishige
Ishizaka, Teruko
Campbell, Dan H.
THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title_full THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title_fullStr THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title_full_unstemmed THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title_short THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
title_sort biological activity of soluble antigen-antibody complexes : ii. physical properties of soluble complexes having skin-irritating activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136941/
https://www.ncbi.nlm.nih.gov/pubmed/13620844
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