IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM

The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms—including leukemias from which no c...

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Detalles Bibliográficos
Autor principal: Friend, Charlotte
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136942/
https://www.ncbi.nlm.nih.gov/pubmed/13620850
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author Friend, Charlotte
author_facet Friend, Charlotte
author_sort Friend, Charlotte
collection PubMed
description The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms—including leukemias from which no causative agent has as yet been obtained,—and sera from leukemic human beings contained no such neutralizing antibody. A formalinized vaccine prepared from filtrates of leukemic spleens induced a significant degree of immunity against the agent, approximately 80 per cent of the vaccinated mice being immune on challenge with it.
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spelling pubmed-21369422008-04-17 IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM Friend, Charlotte J Exp Med Article The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms—including leukemias from which no causative agent has as yet been obtained,—and sera from leukemic human beings contained no such neutralizing antibody. A formalinized vaccine prepared from filtrates of leukemic spleens induced a significant degree of immunity against the agent, approximately 80 per cent of the vaccinated mice being immune on challenge with it. The Rockefeller University Press 1959-01-31 /pmc/articles/PMC2136942/ /pubmed/13620850 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Friend, Charlotte
IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title_full IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title_fullStr IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title_full_unstemmed IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title_short IMMUNOLOGICAL RELATIONSHIPS OF A FILTERABLE AGENT CAUSING A LEUKEMIA IN ADULT MICE : I. THE NEUTRALIZATION OF INFECTIVITY BY SPECIFIC ANTISERUM
title_sort immunological relationships of a filterable agent causing a leukemia in adult mice : i. the neutralization of infectivity by specific antiserum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136942/
https://www.ncbi.nlm.nih.gov/pubmed/13620850
work_keys_str_mv AT friendcharlotte immunologicalrelationshipsofafilterableagentcausingaleukemiainadultmiceitheneutralizationofinfectivitybyspecificantiserum

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