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STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT

A method has been devised to determine the location of infective Shope virus in the papillomas of cottontail rabbits. Frozen sections of the growths were burned selectively with a microcautery to destroy either the keratinized or proliferating layer and the sections were then applied directly to the...

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Detalles Bibliográficos
Autor principal: Noyes, Wilbur Fiske
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136953/
https://www.ncbi.nlm.nih.gov/pubmed/13641566
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author Noyes, Wilbur Fiske
author_facet Noyes, Wilbur Fiske
author_sort Noyes, Wilbur Fiske
collection PubMed
description A method has been devised to determine the location of infective Shope virus in the papillomas of cottontail rabbits. Frozen sections of the growths were burned selectively with a microcautery to destroy either the keratinized or proliferating layer and the sections were then applied directly to the sensitized epidermis of domestic rabbits. No papillomas appeared when the keratohyaline and keratinized areas had been eliminated leaving the proliferating cell layer, whereas papillomas arose when the proliferating cell areas were destroyed leaving the keratohyaline and keratinized layers. The results indicate that infective Shope papilloma virus is situated mainly, perhaps entirely, in the keratohyaline and keratinized areas of cottontail papillomas. This is in accord with the previous disclosure by the fluorescence technique that virus antigen in demonstrable quantity is present only in these situations.
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spelling pubmed-21369532008-04-17 STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT Noyes, Wilbur Fiske J Exp Med Article A method has been devised to determine the location of infective Shope virus in the papillomas of cottontail rabbits. Frozen sections of the growths were burned selectively with a microcautery to destroy either the keratinized or proliferating layer and the sections were then applied directly to the sensitized epidermis of domestic rabbits. No papillomas appeared when the keratohyaline and keratinized areas had been eliminated leaving the proliferating cell layer, whereas papillomas arose when the proliferating cell areas were destroyed leaving the keratohyaline and keratinized layers. The results indicate that infective Shope papilloma virus is situated mainly, perhaps entirely, in the keratohyaline and keratinized areas of cottontail papillomas. This is in accord with the previous disclosure by the fluorescence technique that virus antigen in demonstrable quantity is present only in these situations. The Rockefeller University Press 1959-03-31 /pmc/articles/PMC2136953/ /pubmed/13641566 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Noyes, Wilbur Fiske
STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title_full STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title_fullStr STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title_full_unstemmed STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title_short STUDIES ON THE SHOPE RABBIT PAPILLOMA VIRUS : II. THE LOCATION OF INFECTIVE VIRUS IN PAPILLOMAS OF THE COTTONTAIL RABBIT
title_sort studies on the shope rabbit papilloma virus : ii. the location of infective virus in papillomas of the cottontail rabbit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136953/
https://www.ncbi.nlm.nih.gov/pubmed/13641566
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