THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS

It has been shown that cells from neonatal rabbits are capable of producing considerable amounts of antibody after exposure to antigen in vitro and transfer to x-radiated adult recipients. This suggests that the immunological inadequacy of these neonates is not dependent primarily upon the lack of c...

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Detalles Bibliográficos
Autores principales: Dixon, Frank J., Weigle, William O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136959/
https://www.ncbi.nlm.nih.gov/pubmed/13664875
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author Dixon, Frank J.
Weigle, William O.
author_facet Dixon, Frank J.
Weigle, William O.
author_sort Dixon, Frank J.
collection PubMed
description It has been shown that cells from neonatal rabbits are capable of producing considerable amounts of antibody after exposure to antigen in vitro and transfer to x-radiated adult recipients. This suggests that the immunological inadequacy of these neonates is not dependent primarily upon the lack of cells capable of antibody formation. Both in vitro sensitized neonatal lymphoid cells and in vivo sensitized adult lymphoid cells made much more antibody after transfer to x-rayed adult recipients than to neonatal recipients. Possible reasons for and significance of these observations are pointed out in the discussion.
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spelling pubmed-21369592008-04-17 THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS Dixon, Frank J. Weigle, William O. J Exp Med Article It has been shown that cells from neonatal rabbits are capable of producing considerable amounts of antibody after exposure to antigen in vitro and transfer to x-radiated adult recipients. This suggests that the immunological inadequacy of these neonates is not dependent primarily upon the lack of cells capable of antibody formation. Both in vitro sensitized neonatal lymphoid cells and in vivo sensitized adult lymphoid cells made much more antibody after transfer to x-rayed adult recipients than to neonatal recipients. Possible reasons for and significance of these observations are pointed out in the discussion. The Rockefeller University Press 1959-07-01 /pmc/articles/PMC2136959/ /pubmed/13664875 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dixon, Frank J.
Weigle, William O.
THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title_full THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title_fullStr THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title_full_unstemmed THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title_short THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS : II. ANTIBODY FORMATION BY NEONATAL SPLENIC CELLS TRANSFERRED TO ADULT RECIPIENTS
title_sort nature of the immunologic inadequacy of neonatal rabbits : ii. antibody formation by neonatal splenic cells transferred to adult recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136959/
https://www.ncbi.nlm.nih.gov/pubmed/13664875
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