THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES

Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria...

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Detalles Bibliográficos
Autores principales: Goldberg, Burton, Green, Howard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136969/
https://www.ncbi.nlm.nih.gov/pubmed/13641573
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author Goldberg, Burton
Green, Howard
author_facet Goldberg, Burton
Green, Howard
author_sort Goldberg, Burton
collection PubMed
description Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.
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spelling pubmed-21369692008-04-17 THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES Goldberg, Burton Green, Howard J Exp Med Article Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement. The Rockefeller University Press 1959-05-01 /pmc/articles/PMC2136969/ /pubmed/13641573 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Goldberg, Burton
Green, Howard
THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title_full THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title_fullStr THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title_full_unstemmed THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title_short THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES
title_sort cytotoxic action of immune gamma globulin and complement on krebs ascites tumor cells : i. ultrastructural studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136969/
https://www.ncbi.nlm.nih.gov/pubmed/13641573
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