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STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN
The skin of severely scorbutic guinea pigs which were losing weight contained no detectible neutral salt-extractible collagen. Conditions of growth (weight gain) which actively induced the formation of neutral salt-extractible collagen in the skin of normal guinea pigs failed to do so in the animal...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1959
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136977/ https://www.ncbi.nlm.nih.gov/pubmed/13654628 |
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author | Gross, Jerome |
author_facet | Gross, Jerome |
author_sort | Gross, Jerome |
collection | PubMed |
description | The skin of severely scorbutic guinea pigs which were losing weight contained no detectible neutral salt-extractible collagen. Conditions of growth (weight gain) which actively induced the formation of neutral salt-extractible collagen in the skin of normal guinea pigs failed to do so in the animal with ascorbic acid deficiency. No excess of non-collagenous proline was found in neutral salt extracts of scorbutic skin as compared with normal. Fractionation of these extracts failed to reveal the presence of significant amounts of a soluble component containing unusual proportions of glycine and proline relative to hydroxyproline. It is concluded that deficiency of ascorbic acid either interferes with the synthesis of new collagen in intact skin or causes its destruction and removal as rapidly as it is produced. |
format | Text |
id | pubmed-2136977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1959 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21369772008-04-17 STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN Gross, Jerome J Exp Med Article The skin of severely scorbutic guinea pigs which were losing weight contained no detectible neutral salt-extractible collagen. Conditions of growth (weight gain) which actively induced the formation of neutral salt-extractible collagen in the skin of normal guinea pigs failed to do so in the animal with ascorbic acid deficiency. No excess of non-collagenous proline was found in neutral salt extracts of scorbutic skin as compared with normal. Fractionation of these extracts failed to reveal the presence of significant amounts of a soluble component containing unusual proportions of glycine and proline relative to hydroxyproline. It is concluded that deficiency of ascorbic acid either interferes with the synthesis of new collagen in intact skin or causes its destruction and removal as rapidly as it is produced. The Rockefeller University Press 1959-06-01 /pmc/articles/PMC2136977/ /pubmed/13654628 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Gross, Jerome STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title | STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title_full | STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title_fullStr | STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title_full_unstemmed | STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title_short | STUDIES ON THE FORMATION OF COLLAGEN : IV. EFFECT OF VITAMIN C DEFICIENCY ON THE NEUTRAL SALT-EXTRACTIBLE COLLAGEN OF SKIN |
title_sort | studies on the formation of collagen : iv. effect of vitamin c deficiency on the neutral salt-extractible collagen of skin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136977/ https://www.ncbi.nlm.nih.gov/pubmed/13654628 |
work_keys_str_mv | AT grossjerome studiesontheformationofcollageniveffectofvitamincdeficiencyontheneutralsaltextractiblecollagenofskin |