INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN

The immunological properties of typhoid endotoxin were investigated after incubating it with serum under conditions in which EDC (endotoxin-detoxifying component) was operative. Brief interaction of endotoxin in vitro with this system in serum (human, rabbit, mouse) abolished its antigenicity for ra...

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Detalles Bibliográficos
Autores principales: Landy, Maurice, Trapani, Robert-John, Shear, Murray J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137028/
https://www.ncbi.nlm.nih.gov/pubmed/14413831
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author Landy, Maurice
Trapani, Robert-John
Shear, Murray J.
author_facet Landy, Maurice
Trapani, Robert-John
Shear, Murray J.
author_sort Landy, Maurice
collection PubMed
description The immunological properties of typhoid endotoxin were investigated after incubating it with serum under conditions in which EDC (endotoxin-detoxifying component) was operative. Brief interaction of endotoxin in vitro with this system in serum (human, rabbit, mouse) abolished its antigenicity for rabbits. Suitable modification of the host permitted separate elicitation of toxic and antigenic responses to typhoid endotoxin. Endotoxin altered by EDC was still capable of precipitating specific antibody; moreover, it did so in a manner which resembled that of the haptenic polysaccharide.
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spelling pubmed-21370282008-04-17 INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN Landy, Maurice Trapani, Robert-John Shear, Murray J. J Exp Med Article The immunological properties of typhoid endotoxin were investigated after incubating it with serum under conditions in which EDC (endotoxin-detoxifying component) was operative. Brief interaction of endotoxin in vitro with this system in serum (human, rabbit, mouse) abolished its antigenicity for rabbits. Suitable modification of the host permitted separate elicitation of toxic and antigenic responses to typhoid endotoxin. Endotoxin altered by EDC was still capable of precipitating specific antibody; moreover, it did so in a manner which resembled that of the haptenic polysaccharide. The Rockefeller University Press 1959-10-31 /pmc/articles/PMC2137028/ /pubmed/14413831 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Landy, Maurice
Trapani, Robert-John
Shear, Murray J.
INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title_full INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title_fullStr INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title_full_unstemmed INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title_short INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN
title_sort inactivation of endotoxin by a humoral component : iv. alteration in the immunological properties of typhoid endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137028/
https://www.ncbi.nlm.nih.gov/pubmed/14413831
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AT shearmurrayj inactivationofendotoxinbyahumoralcomponentivalterationintheimmunologicalpropertiesoftyphoidendotoxin

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