Deficient Peptide Loading and MHC Class II Endosomal Sorting in a Human Genetic Immunodeficiency Disease: the Chediak-Higashi Syndrome

The Chediak-Higashi syndrome (CHS) is a human recessive autosomal disease caused by mutations in a single gene encoding a protein of unknown function, called lysosomal-trafficking regulator. All cells in CHS patients bear enlarged lysosomes. In addition, T- and natural killer cell cytotoxicity is de...

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Autores principales: Faigle, Wolfgang, Raposo, Graça, Tenza, Daniele, Pinet, Valérie, Vogt, Anne B., Kropshofer, Harald, Fischer, Alain, de Saint-Basile, Geneviève, Amigorena, Sebastian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137185/
https://www.ncbi.nlm.nih.gov/pubmed/9606205

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