A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN

These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid replacement abolishes the glycogenolytic effect of sublethal doses of endotoxin. It is concluded that th...

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Detalles Bibliográficos
Autores principales: Sanford, Jay P., Barnett, Jack A., Gott, Cora
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137213/
https://www.ncbi.nlm.nih.gov/pubmed/13746229
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author Sanford, Jay P.
Barnett, Jack A.
Gott, Cora
author_facet Sanford, Jay P.
Barnett, Jack A.
Gott, Cora
author_sort Sanford, Jay P.
collection PubMed
description These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid replacement abolishes the glycogenolytic effect of sublethal doses of endotoxin. It is concluded that the derangements of carbohydrate metabolism observed following the administration of sublethal quantities of bacterial endotoxin represent, not a direct hepatotoxic effect of endotoxin, but rather the passive consequence of epinephrine release.
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spelling pubmed-21372132008-04-17 A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN Sanford, Jay P. Barnett, Jack A. Gott, Cora J Exp Med Article These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid replacement abolishes the glycogenolytic effect of sublethal doses of endotoxin. It is concluded that the derangements of carbohydrate metabolism observed following the administration of sublethal quantities of bacterial endotoxin represent, not a direct hepatotoxic effect of endotoxin, but rather the passive consequence of epinephrine release. The Rockefeller University Press 1960-07-01 /pmc/articles/PMC2137213/ /pubmed/13746229 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sanford, Jay P.
Barnett, Jack A.
Gott, Cora
A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title_full A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title_fullStr A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title_full_unstemmed A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title_short A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN
title_sort mechanism of the glycogenolytic action of bacterial endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137213/
https://www.ncbi.nlm.nih.gov/pubmed/13746229
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AT sanfordjayp mechanismoftheglycogenolyticactionofbacterialendotoxin
AT barnettjacka mechanismoftheglycogenolyticactionofbacterialendotoxin
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