CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN

A study has been made of the changes in the opsonic properties of mouse serum and bactericidal activity of mouse peritoneal macrophages at different times following the injection of various doses of lipopolysaccharide. It has been found that changes in the percentage of bacteria phagocytosed and kil...

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Detalles Bibliográficos
Autores principales: Jenkin, Charles, Palmer, D. L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137223/
https://www.ncbi.nlm.nih.gov/pubmed/13789821
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author Jenkin, Charles
Palmer, D. L.
author_facet Jenkin, Charles
Palmer, D. L.
author_sort Jenkin, Charles
collection PubMed
description A study has been made of the changes in the opsonic properties of mouse serum and bactericidal activity of mouse peritoneal macrophages at different times following the injection of various doses of lipopolysaccharide. It has been found that changes in the percentage of bacteria phagocytosed and killed within the mouse peritoneal cavity in a given time could be correlated with changes in the opsonic titre of the serum. Macrophages harvested from the peritoneal cavities of mice injected with endotoxin appear to be more efficient in phagocytosing bacteria in the presence of serum opsonins than macrophages obtained from normal mice. The relative importance of these changes in determining an animal's resistance to infection is discussed.
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spelling pubmed-21372232008-04-17 CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN Jenkin, Charles Palmer, D. L. J Exp Med Article A study has been made of the changes in the opsonic properties of mouse serum and bactericidal activity of mouse peritoneal macrophages at different times following the injection of various doses of lipopolysaccharide. It has been found that changes in the percentage of bacteria phagocytosed and killed within the mouse peritoneal cavity in a given time could be correlated with changes in the opsonic titre of the serum. Macrophages harvested from the peritoneal cavities of mice injected with endotoxin appear to be more efficient in phagocytosing bacteria in the presence of serum opsonins than macrophages obtained from normal mice. The relative importance of these changes in determining an animal's resistance to infection is discussed. The Rockefeller University Press 1960-08-01 /pmc/articles/PMC2137223/ /pubmed/13789821 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jenkin, Charles
Palmer, D. L.
CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title_full CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title_fullStr CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title_full_unstemmed CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title_short CHANGES IN THE TITRE OF SERUM OPSONINS AND PHAGOCYTIC PROPERTIES OF MOUSE PERITONEAL MACROPHAGES FOLLOWING INJECTION OF ENDOTOXIN
title_sort changes in the titre of serum opsonins and phagocytic properties of mouse peritoneal macrophages following injection of endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137223/
https://www.ncbi.nlm.nih.gov/pubmed/13789821
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AT palmerdl changesinthetitreofserumopsoninsandphagocyticpropertiesofmouseperitonealmacrophagesfollowinginjectionofendotoxin

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