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ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS

The skin of atopic patients contains specific reaginic antibodies in all epidermal cells, in unchallenged as well as antigen-challenged areas. The reagins are also present in the epithelial cells of sebaceous glands, sweat glands, hair follicles and also in macrophages and pericytes. Judged by stain...

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Detalles Bibliográficos
Autor principal: Rappaport, Ben Z.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137309/
https://www.ncbi.nlm.nih.gov/pubmed/13739591
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author Rappaport, Ben Z.
author_facet Rappaport, Ben Z.
author_sort Rappaport, Ben Z.
collection PubMed
description The skin of atopic patients contains specific reaginic antibodies in all epidermal cells, in unchallenged as well as antigen-challenged areas. The reagins are also present in the epithelial cells of sebaceous glands, sweat glands, hair follicles and also in macrophages and pericytes. Judged by staining characteristics, their immunologic reaction in tissues with antigen is identical with that of rabbit antibodies. Comparison of tissues stained with conjugated reagins and conjugated anti-human globulin antibodies demonstrates the close relationship of reagins and globulins. In antigen-challenged tissues the macrophages and pericytes become enlarged and stain more intensely with toluidine blue. No such changes in morphology or staining are present in histamine-tested or unchallenged atopic tissues.
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spelling pubmed-21373092008-04-17 ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS Rappaport, Ben Z. J Exp Med Article The skin of atopic patients contains specific reaginic antibodies in all epidermal cells, in unchallenged as well as antigen-challenged areas. The reagins are also present in the epithelial cells of sebaceous glands, sweat glands, hair follicles and also in macrophages and pericytes. Judged by staining characteristics, their immunologic reaction in tissues with antigen is identical with that of rabbit antibodies. Comparison of tissues stained with conjugated reagins and conjugated anti-human globulin antibodies demonstrates the close relationship of reagins and globulins. In antigen-challenged tissues the macrophages and pericytes become enlarged and stain more intensely with toluidine blue. No such changes in morphology or staining are present in histamine-tested or unchallenged atopic tissues. The Rockefeller University Press 1960-10-31 /pmc/articles/PMC2137309/ /pubmed/13739591 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rappaport, Ben Z.
ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title_full ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title_fullStr ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title_full_unstemmed ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title_short ANTIGEN-ANTIBODY REACTIONS IN ALLERGIC HUMAN TISSUES : II. STUDY BY FLUORESCENCE TECHNIQUE OF THE LOCALIZATION OF REAGINS IN HUMAN SKIN AND THEIR RELATION TO GLOBULINS
title_sort antigen-antibody reactions in allergic human tissues : ii. study by fluorescence technique of the localization of reagins in human skin and their relation to globulins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137309/
https://www.ncbi.nlm.nih.gov/pubmed/13739591
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