CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7

Studies correlating the production of infectious adenovirus (types 5 and 7) and the progression of the stages of virus-induced cytologic change in HeLa cells are presented. The results reveal a close relationship between the development of the characteristic nuclear changes and adenovirus synthesis....

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Detalles Bibliográficos
Autores principales: Boyer, Georgianna S., Denny, Floyd W., Miller, Irving, Ginsberg, Harold S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137311/
https://www.ncbi.nlm.nih.gov/pubmed/19867181
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author Boyer, Georgianna S.
Denny, Floyd W.
Miller, Irving
Ginsberg, Harold S.
author_facet Boyer, Georgianna S.
Denny, Floyd W.
Miller, Irving
Ginsberg, Harold S.
author_sort Boyer, Georgianna S.
collection PubMed
description Studies correlating the production of infectious adenovirus (types 5 and 7) and the progression of the stages of virus-induced cytologic change in HeLa cells are presented. The results reveal a close relationship between the development of the characteristic nuclear changes and adenovirus synthesis. They suggest that cells manifesting the first stages of nuclear change, characterized by the appearance of eosinophilic, Feulgen-negative inclusions, contain little or no mature infectious virus, whereas cells in the later stages, with Feulgen-positive and basophilic inclusions, contain relatively large amounts.
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spelling pubmed-21373112008-04-17 CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7 Boyer, Georgianna S. Denny, Floyd W. Miller, Irving Ginsberg, Harold S. J Exp Med Article Studies correlating the production of infectious adenovirus (types 5 and 7) and the progression of the stages of virus-induced cytologic change in HeLa cells are presented. The results reveal a close relationship between the development of the characteristic nuclear changes and adenovirus synthesis. They suggest that cells manifesting the first stages of nuclear change, characterized by the appearance of eosinophilic, Feulgen-negative inclusions, contain little or no mature infectious virus, whereas cells in the later stages, with Feulgen-positive and basophilic inclusions, contain relatively large amounts. The Rockefeller University Press 1960-10-31 /pmc/articles/PMC2137311/ /pubmed/19867181 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Boyer, Georgianna S.
Denny, Floyd W.
Miller, Irving
Ginsberg, Harold S.
CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title_full CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title_fullStr CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title_full_unstemmed CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title_short CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7
title_sort correlation of production of infectious virus with sequential stages of cytologic alteration in hela cells infected with adenoviruses types 5 and 7
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137311/
https://www.ncbi.nlm.nih.gov/pubmed/19867181
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