SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN

Under mild conditions, benzylpenicillin in aqueous solution rearranges to benzylpenicillenic acid, which reacts, under suitable conditions, to form stable disulfides and mercaptides. Through reaction with native proteins or especially with proteins that are enriched in SH groups ("thiolated&quo...

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Detalles Bibliográficos
Autores principales: de Weck, Alain L., Eisen, Herman N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137320/
https://www.ncbi.nlm.nih.gov/pubmed/13720937
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author de Weck, Alain L.
Eisen, Herman N.
author_facet de Weck, Alain L.
Eisen, Herman N.
author_sort de Weck, Alain L.
collection PubMed
description Under mild conditions, benzylpenicillin in aqueous solution rearranges to benzylpenicillenic acid, which reacts, under suitable conditions, to form stable disulfides and mercaptides. Through reaction with native proteins or especially with proteins that are enriched in SH groups ("thiolated"), penicillenic acid forms, ma mixed disulfide linkages, stable highly substituted conjugates. These conjugates are potent antigens, inducing the formation of substantial amounts of antibodies specific for the penicillenic acid structure. The implications of these findings for penicillin hypersensitivity in man are discussed.
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spelling pubmed-21373202008-04-17 SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN de Weck, Alain L. Eisen, Herman N. J Exp Med Article Under mild conditions, benzylpenicillin in aqueous solution rearranges to benzylpenicillenic acid, which reacts, under suitable conditions, to form stable disulfides and mercaptides. Through reaction with native proteins or especially with proteins that are enriched in SH groups ("thiolated"), penicillenic acid forms, ma mixed disulfide linkages, stable highly substituted conjugates. These conjugates are potent antigens, inducing the formation of substantial amounts of antibodies specific for the penicillenic acid structure. The implications of these findings for penicillin hypersensitivity in man are discussed. The Rockefeller University Press 1960-11-30 /pmc/articles/PMC2137320/ /pubmed/13720937 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
de Weck, Alain L.
Eisen, Herman N.
SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title_full SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title_fullStr SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title_full_unstemmed SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title_short SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID : AN ANTIGENIC DETERMINANT DERIVED FROM PENICILLIN
title_sort some immunochemical properties of penicillenic acid : an antigenic determinant derived from penicillin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137320/
https://www.ncbi.nlm.nih.gov/pubmed/13720937
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