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FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES

Direct observations by phase microscopy have demonstrated that small numbers of pathogenic staphylococci survive prolonged periods of time within living human polymorphonuclear leukocytes. Non-pathogenic microorganisms are rapidly destroyed in similar preparations. Leukocytes in which staphylococci...

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Detalles Bibliográficos
Autores principales: Melly, Marian Ann, Thomison, John B., Rogers, David E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137327/
https://www.ncbi.nlm.nih.gov/pubmed/13769271
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author Melly, Marian Ann
Thomison, John B.
Rogers, David E.
author_facet Melly, Marian Ann
Thomison, John B.
Rogers, David E.
author_sort Melly, Marian Ann
collection PubMed
description Direct observations by phase microscopy have demonstrated that small numbers of pathogenic staphylococci survive prolonged periods of time within living human polymorphonuclear leukocytes. Non-pathogenic microorganisms are rapidly destroyed in similar preparations. Leukocytes in which staphylococci remained viable often appeared less vigorous after ingesting microorganisms, but intracellular survival could not be correlated with obvious leukocyte damage with any consistency. Both pathogenic and non-pathogenic cocci were seen to divide within living granulocytes during the first few minutes after ingestion. Occasionally pathogenic staphylococci multiplied in dying cells after long periods of intracellular residence. Phagocytosis of more than one pair of staphylococci by a single leukocyte appeared to act as a stimulus to bacterial destruction. Multiple ingestions of pathogenic staphylococci reduced the incidence of survival of the total microbiol population contained within the cell.
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spelling pubmed-21373272008-04-17 FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES Melly, Marian Ann Thomison, John B. Rogers, David E. J Exp Med Article Direct observations by phase microscopy have demonstrated that small numbers of pathogenic staphylococci survive prolonged periods of time within living human polymorphonuclear leukocytes. Non-pathogenic microorganisms are rapidly destroyed in similar preparations. Leukocytes in which staphylococci remained viable often appeared less vigorous after ingesting microorganisms, but intracellular survival could not be correlated with obvious leukocyte damage with any consistency. Both pathogenic and non-pathogenic cocci were seen to divide within living granulocytes during the first few minutes after ingestion. Occasionally pathogenic staphylococci multiplied in dying cells after long periods of intracellular residence. Phagocytosis of more than one pair of staphylococci by a single leukocyte appeared to act as a stimulus to bacterial destruction. Multiple ingestions of pathogenic staphylococci reduced the incidence of survival of the total microbiol population contained within the cell. The Rockefeller University Press 1960-11-30 /pmc/articles/PMC2137327/ /pubmed/13769271 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Melly, Marian Ann
Thomison, John B.
Rogers, David E.
FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title_full FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title_fullStr FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title_full_unstemmed FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title_short FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
title_sort fate of staphylococci within human leukocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137327/
https://www.ncbi.nlm.nih.gov/pubmed/13769271
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