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HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1960
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137328/ https://www.ncbi.nlm.nih.gov/pubmed/13696375 |
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author | Cremer, Natalie Watson, Dennis W. |
author_facet | Cremer, Natalie Watson, Dennis W. |
author_sort | Cremer, Natalie |
collection | PubMed |
description | The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram-negative bacterial endotoxin. Their chemical composition, therefore, differs from that of Gram-negative bacterial endotoxin. On the basis of tolerance studies it appears that similar non-specific host factors may be involved in the detoxification of both the streptococcal intracellular pyrogenic toxin and the Gram-negative bacterial endotoxin. Detoxification of streptococcal exotoxin requires a more immunologically specific mechanism. Because all the Group A sonic extracts studied elicited reciprocal tolerance to one another, it is suggested that tolerance to the intracellular pyrogenic toxin is not correlated with type-specificity. |
format | Text |
id | pubmed-2137328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1960 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21373282008-04-17 HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN Cremer, Natalie Watson, Dennis W. J Exp Med Article The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram-negative bacterial endotoxin. Their chemical composition, therefore, differs from that of Gram-negative bacterial endotoxin. On the basis of tolerance studies it appears that similar non-specific host factors may be involved in the detoxification of both the streptococcal intracellular pyrogenic toxin and the Gram-negative bacterial endotoxin. Detoxification of streptococcal exotoxin requires a more immunologically specific mechanism. Because all the Group A sonic extracts studied elicited reciprocal tolerance to one another, it is suggested that tolerance to the intracellular pyrogenic toxin is not correlated with type-specificity. The Rockefeller University Press 1960-11-30 /pmc/articles/PMC2137328/ /pubmed/13696375 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Cremer, Natalie Watson, Dennis W. HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title | HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title_full | HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title_fullStr | HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title_full_unstemmed | HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title_short | HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN |
title_sort | host-parasite factors in group a streptococcal infections : a comparative study of streptococcal pyrogenic toxins and gram-negative bacterial endotoxin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137328/ https://www.ncbi.nlm.nih.gov/pubmed/13696375 |
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