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HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN

The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram...

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Detalles Bibliográficos
Autores principales: Cremer, Natalie, Watson, Dennis W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137328/
https://www.ncbi.nlm.nih.gov/pubmed/13696375
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author Cremer, Natalie
Watson, Dennis W.
author_facet Cremer, Natalie
Watson, Dennis W.
author_sort Cremer, Natalie
collection PubMed
description The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram-negative bacterial endotoxin. Their chemical composition, therefore, differs from that of Gram-negative bacterial endotoxin. On the basis of tolerance studies it appears that similar non-specific host factors may be involved in the detoxification of both the streptococcal intracellular pyrogenic toxin and the Gram-negative bacterial endotoxin. Detoxification of streptococcal exotoxin requires a more immunologically specific mechanism. Because all the Group A sonic extracts studied elicited reciprocal tolerance to one another, it is suggested that tolerance to the intracellular pyrogenic toxin is not correlated with type-specificity.
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spelling pubmed-21373282008-04-17 HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN Cremer, Natalie Watson, Dennis W. J Exp Med Article The data presented in this study suggest that Group A streptococci produce two distinct pyrogenic toxins: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram-negative bacterial endotoxin. Their chemical composition, therefore, differs from that of Gram-negative bacterial endotoxin. On the basis of tolerance studies it appears that similar non-specific host factors may be involved in the detoxification of both the streptococcal intracellular pyrogenic toxin and the Gram-negative bacterial endotoxin. Detoxification of streptococcal exotoxin requires a more immunologically specific mechanism. Because all the Group A sonic extracts studied elicited reciprocal tolerance to one another, it is suggested that tolerance to the intracellular pyrogenic toxin is not correlated with type-specificity. The Rockefeller University Press 1960-11-30 /pmc/articles/PMC2137328/ /pubmed/13696375 Text en Copyright © Copyright, 1960, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Cremer, Natalie
Watson, Dennis W.
HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title_full HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title_fullStr HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title_full_unstemmed HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title_short HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS : A COMPARATIVE STUDY OF STREPTOCOCCAL PYROGENIC TOXINS AND GRAM-NEGATIVE BACTERIAL ENDOTOXIN
title_sort host-parasite factors in group a streptococcal infections : a comparative study of streptococcal pyrogenic toxins and gram-negative bacterial endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137328/
https://www.ncbi.nlm.nih.gov/pubmed/13696375
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