HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA

Isoimmune sera, prepared in BALB/c mice by immunization with living or lyophilized tissue from C57Bl/6 mice, were found to possess both hemagglutinating and cytotoxic activity for donor cells. Comparative titrations indicated a good correspondence between these two activities. Absorbtion with living...

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Detalles Bibliográficos
Autores principales: Jensen, Emmerik, Stetson, Chandler A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137373/
https://www.ncbi.nlm.nih.gov/pubmed/13789890
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author Jensen, Emmerik
Stetson, Chandler A.
author_facet Jensen, Emmerik
Stetson, Chandler A.
author_sort Jensen, Emmerik
collection PubMed
description Isoimmune sera, prepared in BALB/c mice by immunization with living or lyophilized tissue from C57Bl/6 mice, were found to possess both hemagglutinating and cytotoxic activity for donor cells. Comparative titrations indicated a good correspondence between these two activities. Absorbtion with living or dead donor tissue caused removal or proportionate reduction of both activities. The results are consistent with the existence in isoimmune sera of a single class of isoantibodies, capable of agglutinating donor cells or of sensitizing them for complement lysis. Living and lyophilized tissue differ quantitatively, but not qualitatively, in their capacity to induce formation of these antibodies.
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spelling pubmed-21373732008-04-17 HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA Jensen, Emmerik Stetson, Chandler A. J Exp Med Article Isoimmune sera, prepared in BALB/c mice by immunization with living or lyophilized tissue from C57Bl/6 mice, were found to possess both hemagglutinating and cytotoxic activity for donor cells. Comparative titrations indicated a good correspondence between these two activities. Absorbtion with living or dead donor tissue caused removal or proportionate reduction of both activities. The results are consistent with the existence in isoimmune sera of a single class of isoantibodies, capable of agglutinating donor cells or of sensitizing them for complement lysis. Living and lyophilized tissue differ quantitatively, but not qualitatively, in their capacity to induce formation of these antibodies. The Rockefeller University Press 1961-03-31 /pmc/articles/PMC2137373/ /pubmed/13789890 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jensen, Emmerik
Stetson, Chandler A.
HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title_full HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title_fullStr HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title_full_unstemmed HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title_short HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS : II. RELATIONSHIP BETWEEN THE HEMAGGLUTINATING AND CYTOTOXIC ACTIVITIES OF CERTAIN ISOIMMUNE SERA
title_sort humoral aspects of the immune response to homografts : ii. relationship between the hemagglutinating and cytotoxic activities of certain isoimmune sera
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137373/
https://www.ncbi.nlm.nih.gov/pubmed/13789890
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AT stetsonchandlera humoralaspectsoftheimmuneresponsetohomograftsiirelationshipbetweenthehemagglutinatingandcytotoxicactivitiesofcertainisoimmunesera

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