THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS

Strain 13 histocompatible guinea pigs developed allergic thyroiditis after immunization with thyroid extracts derived from the same strain or from other strains of guinea pigs. This thyroiditis appeared as early as 5 days after immunization, and by 7 weeks was uniformly present and generally severe....

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Autores principales: McMaster, Philip R. B., Lerner, Edwin M., Exum, Eurmal D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137379/
https://www.ncbi.nlm.nih.gov/pubmed/13774132
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author McMaster, Philip R. B.
Lerner, Edwin M.
Exum, Eurmal D.
author_facet McMaster, Philip R. B.
Lerner, Edwin M.
Exum, Eurmal D.
author_sort McMaster, Philip R. B.
collection PubMed
description Strain 13 histocompatible guinea pigs developed allergic thyroiditis after immunization with thyroid extracts derived from the same strain or from other strains of guinea pigs. This thyroiditis appeared as early as 5 days after immunization, and by 7 weeks was uniformly present and generally severe. 7 weeks after immunization, the anti-thyroid antibody titer correlated with the presence and degree of thyroiditis. However, at certain other times after immunization, the titer did not correlate with the thyroiditis. By contrast, all animals with thyroiditis, which were skin-tested with thyroid extract, exhibited delayed hypersensitivity. Moreover, all those which failed to respond with delayed reactions, when skin-tested, had not developed thyroiditis. The present work correlates the presence of experimental allergic thyroiditis with delayed hypersensitivity.
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spelling pubmed-21373792008-04-17 THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS McMaster, Philip R. B. Lerner, Edwin M. Exum, Eurmal D. J Exp Med Article Strain 13 histocompatible guinea pigs developed allergic thyroiditis after immunization with thyroid extracts derived from the same strain or from other strains of guinea pigs. This thyroiditis appeared as early as 5 days after immunization, and by 7 weeks was uniformly present and generally severe. 7 weeks after immunization, the anti-thyroid antibody titer correlated with the presence and degree of thyroiditis. However, at certain other times after immunization, the titer did not correlate with the thyroiditis. By contrast, all animals with thyroiditis, which were skin-tested with thyroid extract, exhibited delayed hypersensitivity. Moreover, all those which failed to respond with delayed reactions, when skin-tested, had not developed thyroiditis. The present work correlates the presence of experimental allergic thyroiditis with delayed hypersensitivity. The Rockefeller University Press 1961-03-31 /pmc/articles/PMC2137379/ /pubmed/13774132 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McMaster, Philip R. B.
Lerner, Edwin M.
Exum, Eurmal D.
THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title_full THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title_fullStr THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title_full_unstemmed THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title_short THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY TO EXPERIMENTAL ALLERGIC THYROIDITIS IN INBRED GUINEA PIGS
title_sort relationship of delayed hypersensitivity and circulating antibody to experimental allergic thyroiditis in inbred guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137379/
https://www.ncbi.nlm.nih.gov/pubmed/13774132
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