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STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN

Intracutaneous and intravenous injection of pyrogenic, non-lethal doses of bacterial endotoxin were found to increase the infectivity of pathogenic but not non-pathogenic staphylococci in rabbit skin. The increased infectivity of the microorganism was characterized by accelerated multiplication at t...

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Autores principales: Conti, Charles R., Cluff, Leighton E., Scheder, E. Patricia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137420/
https://www.ncbi.nlm.nih.gov/pubmed/13695179
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author Conti, Charles R.
Cluff, Leighton E.
Scheder, E. Patricia
author_facet Conti, Charles R.
Cluff, Leighton E.
Scheder, E. Patricia
author_sort Conti, Charles R.
collection PubMed
description Intracutaneous and intravenous injection of pyrogenic, non-lethal doses of bacterial endotoxin were found to increase the infectivity of pathogenic but not non-pathogenic staphylococci in rabbit skin. The increased infectivity of the microorganism was characterized by accelerated multiplication at the site of inoculation and by the production of necrosis and hemorrhage locally. Histologically, the infection of skin in endotoxin-prepared animals was characterized by necrosis, masses of bacteria, but absence of leukocytic infiltration into the area of bacterial growth. The infectivity of staphylococci in skin of endotoxin-prepared rabbits could be controlled by antibody to the alpha hemolysin of the microorganism. The effect of endotoxin upon staphylococcal infection was demonstrable only within 4 hours after injection of the endotoxin. It could not be prevented with chlorpromazine or dibenamine and was closely related to the effect of endotoxin upon leukocytes. It was suggested that the effect of endotoxin upon leukocytes was probably responsible for its influence upon staphylococcal infection. The implications of these findings in the pathogenesis of staphylococcal infection are discussed.
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spelling pubmed-21374202008-04-17 STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN Conti, Charles R. Cluff, Leighton E. Scheder, E. Patricia J Exp Med Article Intracutaneous and intravenous injection of pyrogenic, non-lethal doses of bacterial endotoxin were found to increase the infectivity of pathogenic but not non-pathogenic staphylococci in rabbit skin. The increased infectivity of the microorganism was characterized by accelerated multiplication at the site of inoculation and by the production of necrosis and hemorrhage locally. Histologically, the infection of skin in endotoxin-prepared animals was characterized by necrosis, masses of bacteria, but absence of leukocytic infiltration into the area of bacterial growth. The infectivity of staphylococci in skin of endotoxin-prepared rabbits could be controlled by antibody to the alpha hemolysin of the microorganism. The effect of endotoxin upon staphylococcal infection was demonstrable only within 4 hours after injection of the endotoxin. It could not be prevented with chlorpromazine or dibenamine and was closely related to the effect of endotoxin upon leukocytes. It was suggested that the effect of endotoxin upon leukocytes was probably responsible for its influence upon staphylococcal infection. The implications of these findings in the pathogenesis of staphylococcal infection are discussed. The Rockefeller University Press 1961-05-01 /pmc/articles/PMC2137420/ /pubmed/13695179 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Conti, Charles R.
Cluff, Leighton E.
Scheder, E. Patricia
STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title_full STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title_fullStr STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title_full_unstemmed STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title_short STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : IV. THE EFFECT OF BACTERIAL ENDOTOXIN
title_sort studies on the pathogenesis of staphylococcal infection : iv. the effect of bacterial endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137420/
https://www.ncbi.nlm.nih.gov/pubmed/13695179
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