STUDIES ON ANEMIA IN F(1) HYBRID MICE INJECTED WITH PARENTAL STRAIN LYMPHOID CELLS

The survival of (51)Cr-labeled erythrocytes has been studied in F(1) hybrid mice in which wasting disease was produced by injection of parental lymphoid cells taken either from lymph nodes and thymus or from the spleen. Coincident with the development of the disease syndrome, there occurred a severe...

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Detalles Bibliográficos
Autores principales: Harriss, Eileen, Currie, Cicely, Kriss, Joseph P., Kaplan, Henry S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137436/
https://www.ncbi.nlm.nih.gov/pubmed/13711856
Descripción
Sumario:The survival of (51)Cr-labeled erythrocytes has been studied in F(1) hybrid mice in which wasting disease was produced by injection of parental lymphoid cells taken either from lymph nodes and thymus or from the spleen. Coincident with the development of the disease syndrome, there occurred a severe anemia accompanied by a sudden loss of circulating labeled erythrocytes, whether host or parental. This finding suggests that the anemia is not due solely to specific immunologic reaction of donor tissue against host erythrocytes.

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