THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM

An investigation of the clearance of bacteria and colloids from the blood stream of mice has shown that both living and inert particles require serum factors (opsonins) in order that they may be phagocytosed by the macrophages of the reticuloendothelial system. It has been demonstrated that after th...

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Detalles Bibliográficos
Autores principales: Jenkin, Charles R., Rowley, Derrick
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137459/
https://www.ncbi.nlm.nih.gov/pubmed/13789822
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author Jenkin, Charles R.
Rowley, Derrick
author_facet Jenkin, Charles R.
Rowley, Derrick
author_sort Jenkin, Charles R.
collection PubMed
description An investigation of the clearance of bacteria and colloids from the blood stream of mice has shown that both living and inert particles require serum factors (opsonins) in order that they may be phagocytosed by the macrophages of the reticuloendothelial system. It has been demonstrated that after the injection of a large dose of colloid there is a depletion of these serum opsonins which appears to account for the reduced rate of clearance of a second dose of colloid or living bacteria, since replacement of these factors leads to normal clearance. The significance of these results is discussed and it is suggested that in "blockaded" animals there is a depletion of serum opsonins rather than a saturation of phagocytic cells.
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spelling pubmed-21374592008-04-17 THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM Jenkin, Charles R. Rowley, Derrick J Exp Med Article An investigation of the clearance of bacteria and colloids from the blood stream of mice has shown that both living and inert particles require serum factors (opsonins) in order that they may be phagocytosed by the macrophages of the reticuloendothelial system. It has been demonstrated that after the injection of a large dose of colloid there is a depletion of these serum opsonins which appears to account for the reduced rate of clearance of a second dose of colloid or living bacteria, since replacement of these factors leads to normal clearance. The significance of these results is discussed and it is suggested that in "blockaded" animals there is a depletion of serum opsonins rather than a saturation of phagocytic cells. The Rockefeller University Press 1961-09-01 /pmc/articles/PMC2137459/ /pubmed/13789822 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jenkin, Charles R.
Rowley, Derrick
THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title_full THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title_fullStr THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title_full_unstemmed THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title_short THE ROLE OF OPSONINS IN THE CLEARANCE OF LIVING AND INERT PARTICLES BY CELLS OF THE RETICULOENDOTHELIAL SYSTEM
title_sort role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137459/
https://www.ncbi.nlm.nih.gov/pubmed/13789822
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