STUDIES ON INFECTION AND IMMUNITY IN EXPERIMENTAL TYPHOID FEVER : III. EFFECT OF PROPHYLACTIC IMMUNIZATION

A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection ind...

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Detalles Bibliográficos
Autores principales: Gaines, Sidney, Landy, Maurice, Edsall, Geoffrey, Mandel, Adrian D., Trapani, R.-J., Benenson, A. S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137464/
https://www.ncbi.nlm.nih.gov/pubmed/13702952
Descripción
Sumario:A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.

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