IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS

Adult mice and hamsters can be made resistant to an isologous transplantable polyoma tumor by an inapparent infection with polyoma virus. This resistance is cell-mediated and seems not to be related to anti-viral serum antibodies. The basis of the resistance appears to be a transplantation type of c...

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Detalles Bibliográficos
Autor principal: Habel, Karl
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137469/
https://www.ncbi.nlm.nih.gov/pubmed/13903377
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author Habel, Karl
author_facet Habel, Karl
author_sort Habel, Karl
collection PubMed
description Adult mice and hamsters can be made resistant to an isologous transplantable polyoma tumor by an inapparent infection with polyoma virus. This resistance is cell-mediated and seems not to be related to anti-viral serum antibodies. The basis of the resistance appears to be a transplantation type of cellular immunity directed against a "foreign" antigen contained in the tumor cell. Evidence has been presented to demonstrate this tumor antigen. It is possible that this phenomenon may explain the lack of oncogenesis by polyoma virus infection of adult mice, and the rarity of naturally occurring polyoma tumors.
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spelling pubmed-21374692008-04-17 IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS Habel, Karl J Exp Med Article Adult mice and hamsters can be made resistant to an isologous transplantable polyoma tumor by an inapparent infection with polyoma virus. This resistance is cell-mediated and seems not to be related to anti-viral serum antibodies. The basis of the resistance appears to be a transplantation type of cellular immunity directed against a "foreign" antigen contained in the tumor cell. Evidence has been presented to demonstrate this tumor antigen. It is possible that this phenomenon may explain the lack of oncogenesis by polyoma virus infection of adult mice, and the rarity of naturally occurring polyoma tumors. The Rockefeller University Press 1962-01-01 /pmc/articles/PMC2137469/ /pubmed/13903377 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Habel, Karl
IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title_full IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title_fullStr IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title_full_unstemmed IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title_short IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESIS
title_sort immunological determinants of polyoma virus oncogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137469/
https://www.ncbi.nlm.nih.gov/pubmed/13903377
work_keys_str_mv AT habelkarl immunologicaldeterminantsofpolyomavirusoncogenesis

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