THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION

Unilateral denervation of the renal pedicle was performed in a series of rabbits. 5 to 21 days later two intravenous injections of E. coli endotoxin were given 18 hours apart. In seven rabbits the generalized Shwartzman reaction developed in the non-denervated kidney. Four of the seven denervated ki...

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Autores principales: Palmerio, C., Ming, S. C., Frank, E., Fine, J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137510/
https://www.ncbi.nlm.nih.gov/pubmed/14483425
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author Palmerio, C.
Ming, S. C.
Frank, E.
Fine, J.
author_facet Palmerio, C.
Ming, S. C.
Frank, E.
Fine, J.
author_sort Palmerio, C.
collection PubMed
description Unilateral denervation of the renal pedicle was performed in a series of rabbits. 5 to 21 days later two intravenous injections of E. coli endotoxin were given 18 hours apart. In seven rabbits the generalized Shwartzman reaction developed in the non-denervated kidney. Four of the seven denervated kidneys did not show the reaction, and in the remaining three only a mild reaction was present. From these and previous observations we conclude that an intact sympathetic nervous system as well as endotoxin from the intestine, are necessary for the production of the generalized Shwartzman reaction.
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spelling pubmed-21375102008-04-17 THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION Palmerio, C. Ming, S. C. Frank, E. Fine, J. J Exp Med Article Unilateral denervation of the renal pedicle was performed in a series of rabbits. 5 to 21 days later two intravenous injections of E. coli endotoxin were given 18 hours apart. In seven rabbits the generalized Shwartzman reaction developed in the non-denervated kidney. Four of the seven denervated kidneys did not show the reaction, and in the remaining three only a mild reaction was present. From these and previous observations we conclude that an intact sympathetic nervous system as well as endotoxin from the intestine, are necessary for the production of the generalized Shwartzman reaction. The Rockefeller University Press 1962-02-28 /pmc/articles/PMC2137510/ /pubmed/14483425 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Palmerio, C.
Ming, S. C.
Frank, E.
Fine, J.
THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title_full THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title_fullStr THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title_full_unstemmed THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title_short THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE GENERALIZED SHWARTZMAN REACTION
title_sort role of the sympathetic nervous system in the generalized shwartzman reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137510/
https://www.ncbi.nlm.nih.gov/pubmed/14483425
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