CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN

Although the livers of rats treated with agents known to suppress bilirubin transport appeared relatively normal on routine histological sections, cytochemical and electron microscopic preparations revealed marked changes in: (a) levels of alkaline phosphatase and apparent ATPase activities of the c...

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Detalles Bibliográficos
Autores principales: Goldfischer, Sidney, Arias, Irwin M., Essner, Edward, Novikoff, Alex B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137511/
https://www.ncbi.nlm.nih.gov/pubmed/13899761
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author Goldfischer, Sidney
Arias, Irwin M.
Essner, Edward
Novikoff, Alex B.
author_facet Goldfischer, Sidney
Arias, Irwin M.
Essner, Edward
Novikoff, Alex B.
author_sort Goldfischer, Sidney
collection PubMed
description Although the livers of rats treated with agents known to suppress bilirubin transport appeared relatively normal on routine histological sections, cytochemical and electron microscopic preparations revealed marked changes in: (a) levels of alkaline phosphatase and apparent ATPase activities of the cell membrane at the sinusoids, bile canaliculi, and between adjacent cells; (b) morphology of the bile canaliculi such as dilatation, fragmentation, vesiculation and reduced numbers of microvilli; (c) the number of lysosomes and their distribution within the cell. Similar changes in the cytochemistry of the liver cell were induced by extrahepatic obstruction.
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spelling pubmed-21375112008-04-17 CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN Goldfischer, Sidney Arias, Irwin M. Essner, Edward Novikoff, Alex B. J Exp Med Article Although the livers of rats treated with agents known to suppress bilirubin transport appeared relatively normal on routine histological sections, cytochemical and electron microscopic preparations revealed marked changes in: (a) levels of alkaline phosphatase and apparent ATPase activities of the cell membrane at the sinusoids, bile canaliculi, and between adjacent cells; (b) morphology of the bile canaliculi such as dilatation, fragmentation, vesiculation and reduced numbers of microvilli; (c) the number of lysosomes and their distribution within the cell. Similar changes in the cytochemistry of the liver cell were induced by extrahepatic obstruction. The Rockefeller University Press 1962-02-28 /pmc/articles/PMC2137511/ /pubmed/13899761 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Goldfischer, Sidney
Arias, Irwin M.
Essner, Edward
Novikoff, Alex B.
CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title_full CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title_fullStr CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title_full_unstemmed CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title_short CYTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT LIVER WITH REDUCED CAPACITY TO TRANSPORT CONJUGATED BILIRUBIN
title_sort cytochemical and electron microscopic studies of rat liver with reduced capacity to transport conjugated bilirubin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137511/
https://www.ncbi.nlm.nih.gov/pubmed/13899761
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AT essneredward cytochemicalandelectronmicroscopicstudiesofratliverwithreducedcapacitytotransportconjugatedbilirubin
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