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A STUDY OF IRON-INDUCED LIVER DAMAGE
The nature of short term iron-induced liver damage and its effect on the hepatic damage induced by other toxins have been studied by the use of histochemical techniques. The results suggest that a reduction of effective available sulfhydryl groups is a critical hepatotoxic property of storage iron....
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1962
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137517/ https://www.ncbi.nlm.nih.gov/pubmed/14007800 |
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author | Witzleben, C. L. Chaffey, N. J. |
author_facet | Witzleben, C. L. Chaffey, N. J. |
author_sort | Witzleben, C. L. |
collection | PubMed |
description | The nature of short term iron-induced liver damage and its effect on the hepatic damage induced by other toxins have been studied by the use of histochemical techniques. The results suggest that a reduction of effective available sulfhydryl groups is a critical hepatotoxic property of storage iron. A reduction of glucose-6-phosphatase, consistently found in iron-loaded animals, demonstrates the sensitivity of the microsomes to the presence of storage iron. The mitochondria appear to be less sensitive, but may be affected under certain conditions. The results suggest that in order for simultaneously acting liver insults to result in additive damage, the mechanisms by which they act must have a critical and relatively specific relationship. |
format | Text |
id | pubmed-2137517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1962 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21375172008-04-17 A STUDY OF IRON-INDUCED LIVER DAMAGE Witzleben, C. L. Chaffey, N. J. J Exp Med Article The nature of short term iron-induced liver damage and its effect on the hepatic damage induced by other toxins have been studied by the use of histochemical techniques. The results suggest that a reduction of effective available sulfhydryl groups is a critical hepatotoxic property of storage iron. A reduction of glucose-6-phosphatase, consistently found in iron-loaded animals, demonstrates the sensitivity of the microsomes to the presence of storage iron. The mitochondria appear to be less sensitive, but may be affected under certain conditions. The results suggest that in order for simultaneously acting liver insults to result in additive damage, the mechanisms by which they act must have a critical and relatively specific relationship. The Rockefeller University Press 1962-03-31 /pmc/articles/PMC2137517/ /pubmed/14007800 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Witzleben, C. L. Chaffey, N. J. A STUDY OF IRON-INDUCED LIVER DAMAGE |
title | A STUDY OF IRON-INDUCED LIVER DAMAGE |
title_full | A STUDY OF IRON-INDUCED LIVER DAMAGE |
title_fullStr | A STUDY OF IRON-INDUCED LIVER DAMAGE |
title_full_unstemmed | A STUDY OF IRON-INDUCED LIVER DAMAGE |
title_short | A STUDY OF IRON-INDUCED LIVER DAMAGE |
title_sort | study of iron-induced liver damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137517/ https://www.ncbi.nlm.nih.gov/pubmed/14007800 |
work_keys_str_mv | AT witzlebencl astudyofironinducedliverdamage AT chaffeynj astudyofironinducedliverdamage AT witzlebencl studyofironinducedliverdamage AT chaffeynj studyofironinducedliverdamage |