THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG

Newborn guinea pigs (less than 24 hours old) are highly susceptible to the lethal effect of endotoxin and susceptibility decreases with age. The vulnerability to endotoxin has not been attributed to hypofunction of either the adrenal gland or the reticuloendothelial system of the newborn, since prio...

Descripción completa

Detalles Bibliográficos
Autor principal: Uhr, Jonathan W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137518/
https://www.ncbi.nlm.nih.gov/pubmed/13923604
_version_ 1782143350419226624
author Uhr, Jonathan W.
author_facet Uhr, Jonathan W.
author_sort Uhr, Jonathan W.
collection PubMed
description Newborn guinea pigs (less than 24 hours old) are highly susceptible to the lethal effect of endotoxin and susceptibility decreases with age. The vulnerability to endotoxin has not been attributed to hypofunction of either the adrenal gland or the reticuloendothelial system of the newborn, since prior injection of corticosteroids provides only partial protection to endotoxin and newborn guinea pigs can efficiently remove colloidal substances from the circulation. In contrast to adults, newborns do not develop a delayed inflammatory reaction following intradermal injection of endotoxin, and after intravenous challenge frequently fail to display neutropenia and sustained fever.
format Text
id pubmed-2137518
institution National Center for Biotechnology Information
language English
publishDate 1962
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21375182008-04-17 THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG Uhr, Jonathan W. J Exp Med Article Newborn guinea pigs (less than 24 hours old) are highly susceptible to the lethal effect of endotoxin and susceptibility decreases with age. The vulnerability to endotoxin has not been attributed to hypofunction of either the adrenal gland or the reticuloendothelial system of the newborn, since prior injection of corticosteroids provides only partial protection to endotoxin and newborn guinea pigs can efficiently remove colloidal substances from the circulation. In contrast to adults, newborns do not develop a delayed inflammatory reaction following intradermal injection of endotoxin, and after intravenous challenge frequently fail to display neutropenia and sustained fever. The Rockefeller University Press 1962-03-31 /pmc/articles/PMC2137518/ /pubmed/13923604 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Uhr, Jonathan W.
THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title_full THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title_fullStr THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title_full_unstemmed THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title_short THE EFFECT OF BACTERIAL ENDOTOXIN ON THE NEWBORN GUINEA PIG
title_sort effect of bacterial endotoxin on the newborn guinea pig
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137518/
https://www.ncbi.nlm.nih.gov/pubmed/13923604
work_keys_str_mv AT uhrjonathanw theeffectofbacterialendotoxinonthenewbornguineapig
AT uhrjonathanw effectofbacterialendotoxinonthenewbornguineapig

Ejemplares similares