HYPERSENSITIVITY IN NEWBORN GUINEA PIGS

Neonatal guinea pigs during the first 2 weeks of life did not indicate the presence of delayed hypersensitivity intradermally, after sensitization with purified soluble antigens in dose levels that induced detectable delayed hypersensitivity in the skin of adults. Although Arthus type allergy was de...

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Detalles Bibliográficos
Autores principales: Salvin, S. B., Gregg, M. B., Smith, R. F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137519/
https://www.ncbi.nlm.nih.gov/pubmed/14496511
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author Salvin, S. B.
Gregg, M. B.
Smith, R. F.
author_facet Salvin, S. B.
Gregg, M. B.
Smith, R. F.
author_sort Salvin, S. B.
collection PubMed
description Neonatal guinea pigs during the first 2 weeks of life did not indicate the presence of delayed hypersensitivity intradermally, after sensitization with purified soluble antigens in dose levels that induced detectable delayed hypersensitivity in the skin of adults. Although Arthus type allergy was detectable in newborns, circulating antibody frequently preceded its appearance by several days. Passive Arthus reactions were not produced in newborns as readily as in adults. Contact hypersensitivity and allergic encephalomyelitis were induced in newborns, but corneal reactions were not. Total body irradiation with 200 r inhibited antibody formation in newborns, as in adults. In addition, the induction period for anamnestic responses in newborns and the antigen elimination rate were the same as in adults. Passive transfer of delayed hypersensitivity from sensitized newborns to normal adults was accomplished.
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spelling pubmed-21375192008-04-17 HYPERSENSITIVITY IN NEWBORN GUINEA PIGS Salvin, S. B. Gregg, M. B. Smith, R. F. J Exp Med Article Neonatal guinea pigs during the first 2 weeks of life did not indicate the presence of delayed hypersensitivity intradermally, after sensitization with purified soluble antigens in dose levels that induced detectable delayed hypersensitivity in the skin of adults. Although Arthus type allergy was detectable in newborns, circulating antibody frequently preceded its appearance by several days. Passive Arthus reactions were not produced in newborns as readily as in adults. Contact hypersensitivity and allergic encephalomyelitis were induced in newborns, but corneal reactions were not. Total body irradiation with 200 r inhibited antibody formation in newborns, as in adults. In addition, the induction period for anamnestic responses in newborns and the antigen elimination rate were the same as in adults. Passive transfer of delayed hypersensitivity from sensitized newborns to normal adults was accomplished. The Rockefeller University Press 1962-03-31 /pmc/articles/PMC2137519/ /pubmed/14496511 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Salvin, S. B.
Gregg, M. B.
Smith, R. F.
HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title_full HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title_fullStr HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title_full_unstemmed HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title_short HYPERSENSITIVITY IN NEWBORN GUINEA PIGS
title_sort hypersensitivity in newborn guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137519/
https://www.ncbi.nlm.nih.gov/pubmed/14496511
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